P2RX4
Gene Ontology Biological Process
- apoptotic signaling pathway [IDA]
- cation transmembrane transport [IDA]
- cellular response to ATP [IDA]
- endothelial cell activation [TAS]
- ion transmembrane transport [IDA]
- membrane depolarization [IDA]
- negative regulation of cardiac muscle hypertrophy [IMP]
- positive regulation of calcium ion transport [NAS]
- positive regulation of calcium ion transport into cytosol [IDA, IMP]
- positive regulation of calcium-mediated signaling [IDA, IMP]
- positive regulation of nitric oxide biosynthetic process [NAS]
- positive regulation of prostaglandin secretion [NAS]
- purinergic nucleotide receptor signaling pathway [IMP]
- regulation of blood pressure [IMP]
- regulation of cardiac muscle contraction [IMP]
- regulation of sodium ion transport [ISS]
- relaxation of cardiac muscle [IMP]
- response to ATP [IDA]
- response to fluid shear stress [IDA]
- sensory perception of pain [ISS]
- signal transduction [IDA]
- tissue homeostasis [NAS]
- transport [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
EIF2B2
Gene Ontology Biological Process
- L-methionine biosynthetic process from methylthioadenosine [IBA]
- cellular protein metabolic process [TAS]
- cellular response to stimulus [IDA]
- central nervous system development [IMP]
- gene expression [TAS]
- myelination [IMP]
- oligodendrocyte development [IMP]
- ovarian follicle development [IMP]
- positive regulation of GTPase activity [IDA, IMP]
- regulation of translational initiation [IBA, TAS]
- response to glucose [ISS]
- response to heat [ISS, TAS]
- response to peptide hormone [ISS]
- translation [TAS]
- translational initiation [IDA, TAS]
Gene Ontology Molecular Function
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network: A Systematic Exploration of the Human Interactome.
Protein interactions form a network whose structure drives cellular function and whose organization informs biological inquiry. Using high-throughput affinity-purification mass spectrometry, we identify interacting partners for 2,594 human proteins in HEK293T cells. The resulting network (BioPlex) contains 23,744 interactions among 7,668 proteins with 86% previously undocumented. BioPlex accurately depicts known complexes, attaining 80%-100% coverage for most CORUM complexes. The network ... [more]
Quantitative Score
- 0.966884836 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 1.0 HEK 293T cells CompPASS score = 0.966884836, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 2.0 (PMID: 28514442) and BioPlex 3.0 (PMID: 33961781). Only scores from within BioPlex 1.0 (PMID: 26186194) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| P2RX4 EIF2B2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.833 | BioGRID | 3042622 |
Curated By
- BioGRID