PRMT2
Gene Ontology Biological Process
- developmental cell growth [ISS]
- histone arginine methylation [IBA]
- histone methylation [IDA, ISS]
- negative regulation of G1/S transition of mitotic cell cycle [ISS]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- peptidyl-arginine methylation, to asymmetrical-dimethyl arginine [IBA]
- positive regulation of apoptotic process [IGI]
- positive regulation of transcription, DNA-templated [IDA]
- protein methylation [TAS]
- regulation of androgen receptor signaling pathway [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function- androgen receptor binding [IPI]
- estrogen receptor binding [IDA, IPI]
- histone methyltransferase activity [IDA]
- histone-arginine N-methyltransferase activity [IBA, ISS]
- peroxisome proliferator activated receptor binding [IPI]
- progesterone receptor binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- protein-arginine N-methyltransferase activity [ISS]
- protein-arginine omega-N asymmetric methyltransferase activity [IBA]
- retinoic acid receptor binding [IPI]
- signal transducer activity [TAS]
- thyroid hormone receptor binding [IPI]
- transcription coactivator activity [IDA]
- androgen receptor binding [IPI]
- estrogen receptor binding [IDA, IPI]
- histone methyltransferase activity [IDA]
- histone-arginine N-methyltransferase activity [IBA, ISS]
- peroxisome proliferator activated receptor binding [IPI]
- progesterone receptor binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- protein-arginine N-methyltransferase activity [ISS]
- protein-arginine omega-N asymmetric methyltransferase activity [IBA]
- retinoic acid receptor binding [IPI]
- signal transducer activity [TAS]
- thyroid hormone receptor binding [IPI]
- transcription coactivator activity [IDA]
Gene Ontology Cellular Component
KANK2
Gene Ontology Biological Process
- negative regulation of G1/S transition of mitotic cell cycle [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of intracellular estrogen receptor signaling pathway [IDA]
- negative regulation of programmed cell death [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network: A Systematic Exploration of the Human Interactome.
Protein interactions form a network whose structure drives cellular function and whose organization informs biological inquiry. Using high-throughput affinity-purification mass spectrometry, we identify interacting partners for 2,594 human proteins in HEK293T cells. The resulting network (BioPlex) contains 23,744 interactions among 7,668 proteins with 86% previously undocumented. BioPlex accurately depicts known complexes, attaining 80%-100% coverage for most CORUM complexes. The network ... [more]
Quantitative Score
- 0.979659641 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 1.0 HEK 293T cells CompPASS score = 0.979659641, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 2.0 (PMID: 28514442) and BioPlex 3.0 (PMID: 33961781). Only scores from within BioPlex 1.0 (PMID: 26186194) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PRMT2 KANK2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.8158 | BioGRID | 3044693 |
Curated By
- BioGRID