TFDP2
Gene Ontology Biological Process
- Notch signaling pathway [TAS]
- gene expression [TAS]
- mitotic cell cycle [TAS]
- positive regulation of transcription from RNA polymerase II promoter [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RB1
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [TAS]
- Ras protein signal transduction [IEP]
- androgen receptor signaling pathway [NAS]
- cell cycle arrest [TAS]
- cell cycle checkpoint [TAS]
- chromatin remodeling [TAS]
- maintenance of mitotic sister chromatid cohesion [IMP]
- mitotic cell cycle [TAS]
- mitotic cell cycle checkpoint [TAS]
- myoblast differentiation [IMP]
- negative regulation of G1/S transition of mitotic cell cycle [TAS]
- negative regulation of protein kinase activity [IPI]
- negative regulation of sequence-specific DNA binding transcription factor activity [TAS]
- negative regulation of transcription from RNA polymerase II promoter during mitosis [TAS]
- negative regulation of transcription, DNA-templated [IDA, TAS]
- positive regulation of mitotic metaphase/anaphase transition [IMP]
- positive regulation of transcription, DNA-templated [NAS]
- protein localization to chromosome, centromeric region [IMP]
- regulation of centromere complex assembly [TAS]
- regulation of cohesin localization to chromatin [IMP]
- regulation of lipid kinase activity [IDA]
- regulation of mitotic cell cycle [IMP]
- regulation of transcription involved in G1/S transition of mitotic cell cycle [TAS]
- sister chromatid biorientation [IMP]
Gene Ontology Molecular Function- DNA binding [TAS]
- androgen receptor binding [NAS]
- core promoter binding [IDA]
- identical protein binding [IPI]
- kinase binding [IDA]
- phosphoprotein binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription coactivator activity [NAS]
- transcription factor binding [IPI]
- ubiquitin protein ligase binding [IPI]
- DNA binding [TAS]
- androgen receptor binding [NAS]
- core promoter binding [IDA]
- identical protein binding [IPI]
- kinase binding [IDA]
- phosphoprotein binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription coactivator activity [NAS]
- transcription factor binding [IPI]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network: A Systematic Exploration of the Human Interactome.
Protein interactions form a network whose structure drives cellular function and whose organization informs biological inquiry. Using high-throughput affinity-purification mass spectrometry, we identify interacting partners for 2,594 human proteins in HEK293T cells. The resulting network (BioPlex) contains 23,744 interactions among 7,668 proteins with 86% previously undocumented. BioPlex accurately depicts known complexes, attaining 80%-100% coverage for most CORUM complexes. The network ... [more]
Quantitative Score
- 0.999657593 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 1.0 HEK 293T cells CompPASS score = 0.999657593, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 2.0 (PMID: 28514442) and BioPlex 3.0 (PMID: 33961781). Only scores from within BioPlex 1.0 (PMID: 26186194) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TFDP2 RB1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9985 | BioGRID | 2233580 | |
| TFDP2 RB1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9994 | BioGRID | 3041559 | |
| RB1 TFDP2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - | |
| RB1 TFDP2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID