BAIT
WNT4
SERKAL, WNT-4, RP1-224A6.7
wingless-type MMTV integration site family, member 4
GO Process (33)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- adrenal gland development [IEP]
- androgen biosynthetic process [IDA]
- canonical Wnt signaling pathway [IDA]
- cell fate commitment [IBA]
- cellular response to transforming growth factor beta stimulus [IEP]
- epithelial to mesenchymal transition [IEP]
- establishment of protein localization to plasma membrane [IDA]
- female gonad development [ISS]
- female sex determination [IMP]
- kidney development [IEP]
- liver development [IEP]
- male gonad development [IEP, IMP]
- mammary gland epithelium development [IEP]
- metanephric mesenchymal cell differentiation [NAS]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of gene expression [IDA]
- negative regulation of male gonad development [IMP]
- negative regulation of steroid biosynthetic process [IDA]
- negative regulation of testicular blood vessel morphogenesis [IMP]
- negative regulation of testosterone biosynthetic process [IMP]
- negative regulation of transcription, DNA-templated [IMP, ISS]
- neuron differentiation [IBA]
- non-canonical Wnt signaling pathway via MAPK cascade [IDA]
- paramesonephric duct development [IMP]
- positive regulation of aldosterone biosynthetic process [IDA]
- positive regulation of bone mineralization [IDA]
- positive regulation of canonical Wnt signaling pathway [IDA]
- positive regulation of collagen biosynthetic process [IDA]
- positive regulation of cortisol biosynthetic process [IDA]
- positive regulation of dermatome development [IDA]
- positive regulation of osteoblast differentiation [IDA]
- positive regulation of transcription, DNA-templated [IDA, ISS]
- protein palmitoylation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
WNT5A
hWNT5A
wingless-type MMTV integration site family, member 5A
GO Process (54)
GO Function (5)
GO Component (7)
Gene Ontology Biological Process
- Wnt signaling pathway [IDA]
- Wnt signaling pathway, calcium modulating pathway [IDA, IMP]
- activation of JUN kinase activity [IDA, IMP]
- activation of MAPK activity [IDA]
- activation of protein kinase B activity [IDA]
- axon guidance [ISS]
- cell fate commitment [IBA]
- cellular protein localization [IDA]
- cellular response to calcium ion [IEP]
- cellular response to interferon-gamma [IEP]
- cellular response to lipopolysaccharide [IEP]
- cellular response to retinoic acid [ISS]
- cellular response to transforming growth factor beta stimulus [IEP]
- embryonic skeletal system development [IMP]
- epithelial to mesenchymal transition [IEP]
- face development [IMP]
- genitalia development [IMP]
- hematopoietic stem cell proliferation [IDA]
- keratinocyte differentiation [IEP]
- lens development in camera-type eye [ISS]
- male gonad development [IEP]
- negative regulation of apoptotic process [IDA]
- negative regulation of canonical Wnt signaling pathway [IDA, IGI]
- negative regulation of fat cell differentiation [IMP]
- negative regulation of mesenchymal cell proliferation [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- neuron differentiation [IBA, ISS]
- olfactory bulb interneuron development [ISS]
- optic cup formation involved in camera-type eye development [ISS]
- palate development [IMP]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of T cell chemotaxis [IMP]
- positive regulation of angiogenesis [IMP]
- positive regulation of cGMP metabolic process [IDA]
- positive regulation of chemokine biosynthetic process [IMP]
- positive regulation of cytokine secretion involved in immune response [IMP]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of fibroblast proliferation [IDA]
- positive regulation of inflammatory response [IMP]
- positive regulation of interleukin-1 beta secretion [IMP]
- positive regulation of interleukin-6 production [IMP]
- positive regulation of macrophage activation [IMP]
- positive regulation of macrophage cytokine production [IMP]
- positive regulation of neuron projection development [ISS]
- positive regulation of ossification [IMP]
- positive regulation of protein catabolic process [IGI]
- positive regulation of protein kinase C signaling [IMP]
- positive regulation of response to cytokine stimulus [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription, DNA-templated [IMP]
- positive regulation of type I interferon-mediated signaling pathway [IDA]
- response to organic substance [IEP]
- wound healing [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network: A Systematic Exploration of the Human Interactome.
Protein interactions form a network whose structure drives cellular function and whose organization informs biological inquiry. Using high-throughput affinity-purification mass spectrometry, we identify interacting partners for 2,594 human proteins in HEK293T cells. The resulting network (BioPlex) contains 23,744 interactions among 7,668 proteins with 86% previously undocumented. BioPlex accurately depicts known complexes, attaining 80%-100% coverage for most CORUM complexes. The network ... [more]
Cell Jul. 16, 2015; 162(2);425-40 [Pubmed: 26186194]
Quantitative Score
- 0.999574368 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 1.0 HEK 293T cells CompPASS score = 0.999574368, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 2.0 (PMID: 28514442) and BioPlex 3.0 (PMID: 33961781). Only scores from within BioPlex 1.0 (PMID: 26186194) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| WNT4 WNT5A | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9893 | BioGRID | 2241550 | |
| WNT4 WNT5A | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9857 | BioGRID | 3041625 |
Curated By
- BioGRID