HTR3C
Gene Ontology Biological Process
Gene Ontology Cellular Component
B4GALT1
Gene Ontology Biological Process
- Notch signaling pathway [TAS]
- binding of sperm to zona pellucida [TAS]
- carbohydrate metabolic process [TAS]
- cellular protein metabolic process [TAS]
- glycosaminoglycan metabolic process [TAS]
- keratan sulfate biosynthetic process [TAS]
- keratan sulfate metabolic process [TAS]
- multicellular organism reproduction [TAS]
- oligosaccharide biosynthetic process [IDA, NAS]
- post-translational protein modification [TAS]
- protein N-linked glycosylation [IDA]
- protein N-linked glycosylation via asparagine [TAS]
- single fertilization [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function- N-acetyllactosamine synthase activity [IDA]
- UDP-galactosyltransferase activity [IDA]
- alpha-tubulin binding [IDA]
- beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [IDA]
- beta-tubulin binding [IPI]
- galactosyltransferase activity [NAS]
- lactose synthase activity [IDA]
- manganese ion binding [IDA]
- protein homodimerization activity [IDA]
- N-acetyllactosamine synthase activity [IDA]
- UDP-galactosyltransferase activity [IDA]
- alpha-tubulin binding [IDA]
- beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [IDA]
- beta-tubulin binding [IPI]
- galactosyltransferase activity [NAS]
- lactose synthase activity [IDA]
- manganese ion binding [IDA]
- protein homodimerization activity [IDA]
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network: A Systematic Exploration of the Human Interactome.
Protein interactions form a network whose structure drives cellular function and whose organization informs biological inquiry. Using high-throughput affinity-purification mass spectrometry, we identify interacting partners for 2,594 human proteins in HEK293T cells. The resulting network (BioPlex) contains 23,744 interactions among 7,668 proteins with 86% previously undocumented. BioPlex accurately depicts known complexes, attaining 80%-100% coverage for most CORUM complexes. The network ... [more]
Quantitative Score
- 0.965519866 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 1.0 HEK 293T cells CompPASS score = 0.965519866, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 2.0 (PMID: 28514442) and BioPlex 3.0 (PMID: 33961781). Only scores from within BioPlex 1.0 (PMID: 26186194) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HTR3C B4GALT1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.8562 | BioGRID | 3061250 |
Curated By
- BioGRID