BAIT
CYP1A1
AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1
GO Process (10)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
- arachidonic acid metabolic process [TAS]
- cellular lipid metabolic process [TAS]
- cellular response to organic cyclic compound [IDA]
- drug metabolic process [IDA]
- epoxygenase P450 pathway [TAS]
- omega-hydroxylase P450 pathway [TAS]
- oxidation-reduction process [IDA]
- small molecule metabolic process [TAS]
- vitamin D metabolic process [IC]
- xenobiotic metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ACADVL
ACAD6, LCACD, VLCAD
acyl-CoA dehydrogenase, very long chain
GO Process (13)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- activation of signaling protein activity involved in unfolded protein response [TAS]
- cellular lipid metabolic process [TAS]
- cellular protein metabolic process [TAS]
- endoplasmic reticulum unfolded protein response [TAS]
- energy derivation by oxidation of organic compounds [TAS]
- epithelial cell differentiation [IEP]
- fatty acid beta-oxidation [TAS]
- fatty acid beta-oxidation using acyl-CoA dehydrogenase [ISS]
- negative regulation of fatty acid biosynthetic process [ISS]
- negative regulation of fatty acid oxidation [ISS]
- regulation of cholesterol metabolic process [ISS]
- small molecule metabolic process [TAS]
- temperature homeostasis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network: A Systematic Exploration of the Human Interactome.
Protein interactions form a network whose structure drives cellular function and whose organization informs biological inquiry. Using high-throughput affinity-purification mass spectrometry, we identify interacting partners for 2,594 human proteins in HEK293T cells. The resulting network (BioPlex) contains 23,744 interactions among 7,668 proteins with 86% previously undocumented. BioPlex accurately depicts known complexes, attaining 80%-100% coverage for most CORUM complexes. The network ... [more]
Cell Jul. 16, 2015; 162(2);425-40 [Pubmed: 26186194]
Quantitative Score
- 0.951323266 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 1.0 HEK 293T cells CompPASS score = 0.951323266, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 2.0 (PMID: 28514442) and BioPlex 3.0 (PMID: 33961781). Only scores from within BioPlex 1.0 (PMID: 26186194) should be compared directly.
Curated By
- BioGRID