EREG
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- activation of MAPK activity [IBA]
- anatomical structure morphogenesis [TAS]
- cell-cell signaling [IDA]
- cytokine-mediated signaling pathway [IDA]
- epidermal growth factor receptor signaling pathway [IBA, ISS, TAS]
- female meiotic division [ISS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- keratinocyte differentiation [TAS]
- keratinocyte proliferation [IDA]
- luteinizing hormone signaling pathway [ISS]
- mRNA transcription [IDA]
- negative regulation of cell proliferation [ISS]
- negative regulation of epithelial cell proliferation [TAS]
- negative regulation of smooth muscle cell differentiation [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- oocyte maturation [ISS]
- organ morphogenesis [TAS]
- ovarian cumulus expansion [ISS]
- ovulation [ISS]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of DNA replication [IDA, ISS]
- positive regulation of cell proliferation [IDA, ISS]
- positive regulation of cytokine biosynthetic process [IDA]
- positive regulation of cytokine production [ISS]
- positive regulation of epidermal growth factor-activated receptor activity [ISS]
- positive regulation of fibroblast proliferation [IDA]
- positive regulation of innate immune response [ISS]
- positive regulation of interleukin-6 biosynthetic process [ISS]
- positive regulation of mitosis [ISS]
- positive regulation of phosphorylation [IDA, ISS]
- positive regulation of protein kinase activity [IDA]
- positive regulation of smooth muscle cell proliferation [ISS]
- primary follicle stage [ISS]
- wound healing [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RAB4A
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network: A Systematic Exploration of the Human Interactome.
Protein interactions form a network whose structure drives cellular function and whose organization informs biological inquiry. Using high-throughput affinity-purification mass spectrometry, we identify interacting partners for 2,594 human proteins in HEK293T cells. The resulting network (BioPlex) contains 23,744 interactions among 7,668 proteins with 86% previously undocumented. BioPlex accurately depicts known complexes, attaining 80%-100% coverage for most CORUM complexes. The network ... [more]
Quantitative Score
- 0.986789976 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 1.0 HEK 293T cells CompPASS score = 0.986789976, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 2.0 (PMID: 28514442) and BioPlex 3.0 (PMID: 33961781). Only scores from within BioPlex 1.0 (PMID: 26186194) should be compared directly.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
EREG RAB4A | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9864 | BioGRID | 2242846 | |
EREG RAB4A | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.8834 | BioGRID | 3048336 |
Curated By
- BioGRID