IFNA5
Gene Ontology Biological Process
- B cell differentiation [IBA]
- B cell proliferation [IBA]
- T cell activation involved in immune response [IBA]
- adaptive immune response [IBA]
- blood coagulation [TAS]
- cytokine-mediated signaling pathway [IBA, TAS]
- humoral immune response [IBA]
- innate immune response [IBA, TAS]
- natural killer cell activation involved in immune response [IBA]
- positive regulation of peptidyl-serine phosphorylation of STAT protein [IBA]
- regulation of MHC class I biosynthetic process [IBA]
- regulation of type I interferon-mediated signaling pathway [TAS]
- response to exogenous dsRNA [IBA]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
IFIT1
Gene Ontology Biological Process
- cellular response to exogenous dsRNA [IDA]
- cellular response to type I interferon [IDA]
- cytokine-mediated signaling pathway [TAS]
- intracellular transport of viral protein in host cell [IDA]
- negative regulation of defense response to virus by host [IDA]
- negative regulation of helicase activity [IDA]
- negative regulation of protein binding [IDA]
- negative regulation of viral genome replication [IMP]
- positive regulation of viral genome replication [IDA]
- response to virus [IDA, IMP]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network: A Systematic Exploration of the Human Interactome.
Protein interactions form a network whose structure drives cellular function and whose organization informs biological inquiry. Using high-throughput affinity-purification mass spectrometry, we identify interacting partners for 2,594 human proteins in HEK293T cells. The resulting network (BioPlex) contains 23,744 interactions among 7,668 proteins with 86% previously undocumented. BioPlex accurately depicts known complexes, attaining 80%-100% coverage for most CORUM complexes. The network ... [more]
Quantitative Score
- 0.999705806 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 1.0 HEK 293T cells CompPASS score = 0.999705806, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 2.0 (PMID: 28514442) and BioPlex 3.0 (PMID: 33961781). Only scores from within BioPlex 1.0 (PMID: 26186194) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| IFNA5 IFIT1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9976 | BioGRID | 2235050 | |
| IFNA5 IFIT1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9995 | BioGRID | 3099096 |
Curated By
- BioGRID