BAIT

CDKN1A

CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

Cell Cycle - Senescence Project

Human Papilloma Virus (HPV) Project

GO Process (27)

GO Function (4)

GO Component (6)

Gene Ontology Biological Process

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [IDA, TAS]

Fc-epsilon receptor signaling pathway [TAS]

G1/S transition of mitotic cell cycle [IDA, TAS]

G2/M transition of mitotic cell cycle [IMP]

Ras protein signal transduction [IEP]

cell cycle arrest [IDA, IMP]

cellular response to DNA damage stimulus [IMP]

cellular response to extracellular stimulus [IMP]

cellular response to ionizing radiation [IMP]

cellular senescence [IMP]

epidermal growth factor receptor signaling pathway [TAS]

fibroblast growth factor receptor signaling pathway [TAS]

innate immune response [TAS]

intrinsic apoptotic signaling pathway [TAS]

mitotic cell cycle [TAS]

negative regulation of G1/S transition of mitotic cell cycle [IGI]

negative regulation of cell growth [IDA]

negative regulation of cell proliferation [IDA, IMP]

negative regulation of phosphorylation [IDA]

neurotrophin TRK receptor signaling pathway [TAS]

phosphatidylinositol-mediated signaling [TAS]

positive regulation of fibroblast proliferation [IMP]

positive regulation of protein kinase activity [IDA]

positive regulation of reactive oxygen species metabolic process [IMP]

protein phosphorylation [IDA]

regulation of cyclin-dependent protein serine/threonine kinase activity [TAS]

stress-induced premature senescence [TAS]

Gene Ontology Molecular Function

cyclin-dependent protein kinase activating kinase activity [IDA]
cyclin-dependent protein serine/threonine kinase inhibitor activity [TAS]
protein binding [IPI]
ubiquitin protein ligase binding [IPI]

Gene Ontology Cellular Component

PCNA-p21 complex [IDA]

cyclin-dependent protein kinase holoenzyme complex [IDA]

intracellular membrane-bounded organelle [IDA]

nucleoplasm [IDA, TAS]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

PREY

CCDC85B

DIPA

coiled-coil domain containing 85B

GO Process (3)

GO Function (1)

GO Component (2)

Gene Ontology Biological Process

negative regulation of cell growth [IDA]

negative regulation of fat cell differentiation [ISS]

negative regulation of transcription, DNA-templated [IDA]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

centrosome [IDA]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Towards a proteome-scale map of the human protein-protein interaction network.

Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M

Systematic mapping of protein-protein interactions, or 'interactome' mapping, was initiated in model organisms, starting with defined biological processes and then expanding to the scale of the proteome. Although far from complete, such maps have revealed global topological and dynamic features of interactome networks that relate to known biological properties, suggesting that a human interactome map will provide insight into development ... [more]

Nature Oct. 20, 2005; 437(7062);1173-8 [Pubmed: 16189514]

Throughput

High Throughput

Curated By

BioGRID