BAIT
PRKAR1A
ACRDYS1, ADOHR, CAR, CNC, CNC1, PKR1, PPNAD1, PRKAR1, TSE1
protein kinase, cAMP-dependent, regulatory, type I, alpha
GO Process (17)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- activation of phospholipase C activity [TAS]
- activation of protein kinase A activity [TAS]
- blood coagulation [TAS]
- cellular response to glucagon stimulus [TAS]
- energy reserve metabolic process [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- intracellular signal transduction [TAS]
- negative regulation of cAMP-dependent protein kinase activity [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- regulation of insulin secretion [TAS]
- regulation of transcription from RNA polymerase II promoter [TAS]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
- transmembrane transport [TAS]
- water transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PYCARD
ASC, CARD5, TMS, TMS-1, TMS1
PYD and CARD domain containing
GO Process (48)
GO Function (4)
GO Component (9)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [NAS]
- activation of innate immune response [IDA]
- apoptotic process [TAS]
- cellular response to interleukin-1 [IDA]
- cellular response to lipopolysaccharide [IDA]
- cellular response to tumor necrosis factor [IDA]
- defense response to Gram-negative bacterium [IMP]
- defense response to virus [IDA]
- innate immune response [TAS]
- intrinsic apoptotic signaling pathway by p53 class mediator [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IMP]
- macropinocytosis [ISS]
- myeloid dendritic cell activation [IMP]
- myeloid dendritic cell activation involved in immune response [ISS]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- negative regulation of NF-kappaB transcription factor activity [IMP]
- negative regulation of interferon-beta production [IMP]
- negative regulation of protein serine/threonine kinase activity [IDA]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of JNK cascade [IMP]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of T cell activation [IMP]
- positive regulation of T cell migration [ISS]
- positive regulation of actin filament polymerization [ISS]
- positive regulation of activated T cell proliferation [ISS]
- positive regulation of adaptive immune response [IMP]
- positive regulation of antigen processing and presentation of peptide antigen via MHC class II [ISS]
- positive regulation of apoptotic process [IDA]
- positive regulation of chemokine secretion [IMP]
- positive regulation of cysteine-type endopeptidase activity [IDA]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- positive regulation of extrinsic apoptotic signaling pathway [IDA]
- positive regulation of interferon-gamma production [ISS]
- positive regulation of interleukin-1 beta secretion [IDA]
- positive regulation of interleukin-10 secretion [IMP]
- positive regulation of interleukin-6 production [ISS]
- positive regulation of interleukin-6 secretion [IMP]
- positive regulation of interleukin-8 secretion [IMP]
- positive regulation of phagocytosis [ISS]
- positive regulation of release of cytochrome c from mitochondria [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of tumor necrosis factor production [IMP]
- regulation of intrinsic apoptotic signaling pathway [IDA]
- regulation of protein stability [ISS]
- regulation of tumor necrosis factor-mediated signaling pathway [IMP]
- signal transduction [NAS]
- tumor necrosis factor-mediated signaling pathway [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Towards a proteome-scale map of the human protein-protein interaction network.
Systematic mapping of protein-protein interactions, or 'interactome' mapping, was initiated in model organisms, starting with defined biological processes and then expanding to the scale of the proteome. Although far from complete, such maps have revealed global topological and dynamic features of interactome networks that relate to known biological properties, suggesting that a human interactome map will provide insight into development ... [more]
Nature Oct. 20, 2005; 437(7062);1173-8 [Pubmed: 16189514]
Throughput
- High Throughput
Curated By
- BioGRID