BAIT
GRB10
GRB-IR, Grb-10, IRBP, MEG1, RSS
growth factor receptor-bound protein 10
GO Process (8)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- insulin receptor signaling pathway [ISS, TAS]
- negative regulation of Wnt signaling pathway [IDA]
- negative regulation of glucose import [ISS]
- negative regulation of glycogen biosynthetic process [ISS]
- negative regulation of insulin receptor signaling pathway [ISS]
- positive regulation of phosphorylation [ISS]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IDA]
- response to insulin [ISS]
Gene Ontology Molecular Function
Homo sapiens
PREY
CHFR
RNF116, RNF196
checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
GO Process (3)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Insulin-induced cell division is controlled by the adaptor Grb14 in a Chfr-dependent manner.
Beyond its key role in the control of energy metabolism, insulin is also an important regulator of cell division and neoplasia. However, the molecular events involved in insulin-driven cell proliferation are not fully elucidated. Here, we show that the ubiquitin ligase Chfr, a checkpoint protein involved in G2/M transition, is a new effector involved in the control of insulin-induced cell ... [more]
Cell. Signal. Apr. 01, 2015; 27(4);798-806 [Pubmed: 25578860]
Throughput
- Low Throughput
Curated By
- BioGRID