PAP2
Gene Ontology Biological Process
- U4 snRNA 3'-end processing [IGI, IMP]
- base-excision repair [IGI, IMP]
- histone mRNA catabolic process [IGI]
- meiotic DNA double-strand break formation [IMP]
- ncRNA polyadenylation [IDA, IGI, IMP]
- negative regulation of DNA recombination [IMP]
- nuclear mRNA surveillance of mRNA 3'-end processing [IGI]
- nuclear polyadenylation-dependent CUT catabolic process [IGI, IMP]
- nuclear polyadenylation-dependent antisense transcript catabolic process [IMP]
- nuclear polyadenylation-dependent mRNA catabolic process [IGI]
- nuclear polyadenylation-dependent rRNA catabolic process [IGI, IMP]
- nuclear polyadenylation-dependent snRNA catabolic process [IMP]
- nuclear polyadenylation-dependent snoRNA catabolic process [IGI, IMP]
- nuclear polyadenylation-dependent tRNA catabolic process [IDA, IGI, IMP]
- polyadenylation-dependent mRNA catabolic process [IMP]
- polyadenylation-dependent snoRNA 3'-end processing [IGI]
- snoRNA polyadenylation [IGI]
- tRNA modification [IMP]
Gene Ontology Molecular Function
MUD2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
Cotranscriptional recruitment of yeast TRAMP complex to intronic sequences promotes optimal pre-mRNA splicing.
Most unwanted RNA transcripts in the nucleus of eukaryotic cells, such as splicing-defective pre-mRNAs and spliced-out introns, are rapidly degraded by the nuclear exosome. In budding yeast, a number of these unwanted RNA transcripts, including spliced-out introns, are first recognized by the nuclear exosome cofactor Trf4/5p-Air1/2p-Mtr4p polyadenylation (TRAMP) complex before subsequent nuclear-exosome-mediated degradation. However, it remains unclear when spliced-out introns ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
Additional Notes
- Figure 7
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PAP2 MUD2 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1808 | BioGRID | 412780 | |
| PAP2 MUD2 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1372 | BioGRID | 2180495 | |
| PAP2 MUD2 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 1238465 |
Curated By
- BioGRID