BAIT
HTR6
5-HT6, 5-HT6R
5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
GO Process (3)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CDK5
PSSALRE
cyclin-dependent kinase 5
GO Process (25)
GO Function (8)
GO Component (10)
Gene Ontology Biological Process
- axon extension [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- cell proliferation [TAS]
- negative regulation of neuron death [IDA]
- negative regulation of proteolysis [IMP]
- negative regulation of transcription, DNA-templated [IMP]
- neuron apoptotic process [TAS]
- neuron differentiation [ISS, TAS]
- neuron migration [TAS]
- neuron projection development [ISS]
- oligodendrocyte differentiation [IDA]
- peptidyl-serine phosphorylation [IDA]
- phosphorylation [IDA]
- positive regulation of actin cytoskeleton reorganization [TAS]
- positive regulation of neuron apoptotic process [ISS]
- regulation of apoptotic process [TAS]
- regulation of cell cycle arrest [TAS]
- regulation of dendritic spine morphogenesis [ISS]
- regulation of synaptic plasticity [ISS, TAS]
- regulation of synaptic vesicle recycling [NAS]
- synapse assembly [TAS]
- synaptic transmission [TAS]
- synaptic vesicle endocytosis [TAS]
- synaptic vesicle exocytosis [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.
Cognitive deficits in schizophrenia severely compromise quality of life and are poorly controlled by current antipsychotics. While 5-HT(6) receptor blockade holds special promise, molecular substrates underlying their control of cognition remain unclear. Using a proteomic strategy, we show that 5-HT(6) receptors physically interact with several proteins of the mammalian target of rapamycin (mTOR) pathway, including mTOR. Further, 5-HT(6) receptor activation ... [more]
EMBO Mol Med Oct. 01, 2012; 4(10);1043-56 [Pubmed: 23027611]
Throughput
- High Throughput
Curated By
- BioGRID