BAIT
HTR6
5-HT6, 5-HT6R
5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
GO Process (3)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
COG3
SEC34
component of oligomeric golgi complex 3
GO Process (8)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- ER to Golgi vesicle-mediated transport [IDA]
- Golgi organization [IGI, IMP]
- intra-Golgi vesicle-mediated transport [IDA]
- protein glycosylation [IMP]
- protein localization to organelle [IMP]
- protein stabilization [IMP]
- retrograde transport, vesicle recycling within Golgi [IBA]
- retrograde vesicle-mediated transport, Golgi to ER [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.
Cognitive deficits in schizophrenia severely compromise quality of life and are poorly controlled by current antipsychotics. While 5-HT(6) receptor blockade holds special promise, molecular substrates underlying their control of cognition remain unclear. Using a proteomic strategy, we show that 5-HT(6) receptors physically interact with several proteins of the mammalian target of rapamycin (mTOR) pathway, including mTOR. Further, 5-HT(6) receptor activation ... [more]
EMBO Mol Med Oct. 01, 2012; 4(10);1043-56 [Pubmed: 23027611]
Throughput
- High Throughput
Curated By
- BioGRID