BAIT
HTR6
5-HT6, 5-HT6R
5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
GO Process (3)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
EXOC2
SEC5, SEC5L1, Sec5p, RP11-164H16.2
exocyst complex component 2
GO Process (2)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.
Cognitive deficits in schizophrenia severely compromise quality of life and are poorly controlled by current antipsychotics. While 5-HT(6) receptor blockade holds special promise, molecular substrates underlying their control of cognition remain unclear. Using a proteomic strategy, we show that 5-HT(6) receptors physically interact with several proteins of the mammalian target of rapamycin (mTOR) pathway, including mTOR. Further, 5-HT(6) receptor activation ... [more]
EMBO Mol Med Oct. 01, 2012; 4(10);1043-56 [Pubmed: 23027611]
Throughput
- High Throughput
Curated By
- BioGRID