HTR6
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [ISO]
- learning [ISO]
- long-term synaptic potentiation [ISO]
- negative regulation of acetylcholine secretion, neurotransmission [ISO]
- negative regulation of gamma-aminobutyric acid secretion [ISO]
- negative regulation of glutamate secretion [ISO]
- positive regulation of TOR signaling [ISO]
- positive regulation of dopamine secretion [ISO]
- positive regulation of gamma-aminobutyric acid secretion [ISO]
- serotonin receptor signaling pathway [ISO]
Gene Ontology Molecular Function
RHEB
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.
Cognitive deficits in schizophrenia severely compromise quality of life and are poorly controlled by current antipsychotics. While 5-HT(6) receptor blockade holds special promise, molecular substrates underlying their control of cognition remain unclear. Using a proteomic strategy, we show that 5-HT(6) receptors physically interact with several proteins of the mammalian target of rapamycin (mTOR) pathway, including mTOR. Further, 5-HT(6) receptor activation ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID