MMS4
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NSE4
Gene Ontology Biological Process
- DNA repair [IMP, IPI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Smc5/6 coordinates formation and resolution of joint molecules with chromosome morphology to ensure meiotic divisions.
During meiosis, Structural Maintenance of Chromosome (SMC) complexes underpin two fundamental features of meiosis: homologous recombination and chromosome segregation. While meiotic functions of the cohesin and condensin complexes have been delineated, the role of the third SMC complex, Smc5/6, remains enigmatic. Here we identify specific, essential meiotic functions for the Smc5/6 complex in homologous recombination and the regulation of cohesin. ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: meiotic recombination (APO:0000040)
Additional Notes
- Figure 7
- genetic complex
- mms4 yen1 slx4 nse4 quadruple mutant shows reduced crossovers
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NSE4 MMS4 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.2945 | BioGRID | 1965271 | |
| MMS4 NSE4 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.519 | BioGRID | 2028795 | |
| MMS4 NSE4 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.4187 | BioGRID | 2429032 |
Curated By
- BioGRID