CIK1
Gene Ontology Biological Process
- establishment of mitotic spindle orientation [TAS]
- karyogamy involved in conjugation with cellular fusion [IMP]
- meiotic nuclear division [IDA, IMP]
- mitotic sister chromatid segregation [TAS]
- mitotic spindle organization in nucleus [TAS]
- nuclear migration involved in conjugation with cellular fusion [IMP]
- regulation of mitotic spindle organization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MAD2
Gene Ontology Biological Process
Gene Ontology Cellular Component
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
The signaling network that silences the spindle assembly checkpoint upon the establishment of chromosome bipolar attachment.
Improper kinetochore attachments activate the spindle assembly checkpoint (SAC) to prevent anaphase onset, but it is poorly understood how this checkpoint is silenced to allow anaphase onset. Chromosome bipolar attachment applies tension on sister kinetochores, and the lack of tension delays anaphase onset. In budding yeast, the delay induced by tension defects depends on the intact SAC as well as ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: cell size (APO:0000052)
Additional Notes
- Figure 1
- MAD2 deletion suppresses increase in large budded cells caused by overexpression of Cik1 coiled-coil domain
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CIK1 MAD2 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -12.038 | BioGRID | 213724 | |
| MAD2 CIK1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.4406 | BioGRID | 391440 | |
| CIK1 MAD2 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.4406 | BioGRID | 405584 | |
| CIK1 MAD2 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.5279 | BioGRID | 2164420 | |
| MAD2 CIK1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | High | - | BioGRID | 167471 | |
| MAD2 CIK1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 166718 |
Curated By
- BioGRID