BAIT
ASPSCR1
ASPCR1, ASPL, ASPS, RCC17, TUG, UBXD9, UBXN9
alveolar soft part sarcoma chromosome region, candidate 1
GO Process (1)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NSF
SKD2
N-ethylmaleimide-sensitive factor
GO Process (10)
GO Function (7)
GO Component (8)
Gene Ontology Biological Process
- ATP catabolic process [ISS]
- Golgi to plasma membrane protein transport [IBA]
- Golgi vesicle docking [IBA]
- exocytosis [TAS]
- intra-Golgi vesicle-mediated transport [IBA]
- plasma membrane fusion [TAS]
- positive regulation of receptor recycling [IDA]
- regulation of exocytosis [ISS]
- synaptic transmission [TAS]
- vesicle-mediated transport [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Human ASPL/TUG interacts with p97 and complements the proteasome mislocalization of a yeast ubx4 mutant, but not the ER-associated degradation defect.
In mammalian cells, ASPL is involved in insulin-stimulated redistribution of the glucose transporter GLUT4 and assembly of the Golgi apparatus. Its putative yeast orthologue, Ubx4, is important for proteasome localization, endoplasmic reticulum-associated protein degradation (ERAD), and UV-induced degradation of RNA polymerase.Here, we show that ASPL is a cofactor of the hexameric ATPase complex, known as p97 or VCP in mammals ... [more]
BMC Cell Biol. Aug. 01, 2014; 15(0);31 [Pubmed: 25078495]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
ASPSCR1 NSF | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID