A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

The BiP molecular chaperone plays multiple roles during the biogenesis of torsinA, an AAA+ ATPase associated with the neurological disease early-onset torsion dystonia.

Zacchi LF, Wu HC, Bell SL, Millen L, Paton AW, Paton JC, Thomas PJ, Zolkiewski M, Brodsky JL

Early-onset torsion dystonia (EOTD) is a neurological disorder characterized by involuntary and sustained muscle contractions that can lead to paralysis and abnormal posture. EOTD is associated with the deletion of a glutamate (Î”E) in torsinA, an endoplasmic reticulum (ER) resident AAA(+) ATPase. To date, the effect of Î”E on torsinA and the reason that this mutation results in EOTD are ... [more]

J. Biol. Chem. May. 02, 2014; 289(18);12727-47 [Pubmed: 24627482]

Throughput

Low Throughput

Ontology Terms

phenotype: protein/peptide modification (APO:0000131)

Additional Notes

Figure 4
glycosylation defect in double mutant

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
SCJ1 JEM1	Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.	Silberstein S (1998)	Low	-	BioGRID	437291
SCJ1 JEM1	Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.	Costanzo M (2010)	High	-0.3025	BioGRID	405780
JEM1 SCJ1	Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.	Costanzo M (2010)	High	-0.3025	BioGRID	390982
JEM1 SCJ1	Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.	Costanzo M (2016)	High	-0.2051	BioGRID	2135689
SCJ1 JEM1	Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.	Costanzo M (2016)	High	-0.2674	BioGRID	2164674
SCJ1 JEM1	Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.	Schuldiner M (2005)	High	-	BioGRID	211008
JEM1 SCJ1	Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.	Schuldiner M (2005)	High	-3.3994	BioGRID	209048
JEM1 SCJ1	Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.	Makio T (2008)	Low	-	BioGRID	300261
JEM1 SCJ1	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Nishikawa S (1997)	Low	-	BioGRID	158170
SCJ1 JEM1	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Silberstein S (1998)	Low	-	BioGRID	158742

Curated By

BioGRID

Interaction Summary

JEM1

Gene Ontology Biological Process

Gene Ontology Molecular Function

chaperone binding [ISS]unfolded protein binding [ISS]

Gene Ontology Cellular Component

SCJ1