HNRNPA1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DDX1
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- DNA duplex unwinding [IDA]
- double-strand break repair [IDA]
- multicellular organismal development [IEP]
- nucleic acid phosphodiester bond hydrolysis [IDA]
- regulation of translational initiation [NAS]
- spliceosomal complex assembly [NAS]
- tRNA splicing, via endonucleolytic cleavage and ligation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling.
The increased cap-independent translation of anti-apoptotic proteins is involved in the development of drug resistance in lung cancer but signalling events regulating this are poorly understood. Fibroblast growth factor 2 (FGF-2) signalling-induced S6 kinase 2 (S6K2) activation is necessary, but the downstream mediator(s) coupling this kinase to the translational response is unknown. Here, we show that S6K2 binds and phosphorylates ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HNRNPA1 DDX1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 669364 | |
| DDX1 HNRNPA1 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.759 | BioGRID | 746037 |
Curated By
- BioGRID