BAIT
HNRNPA1
ALS19, ALS20, HNRPA1, HNRPA1L3, IBMPFD3, hnRNP A1, hnRNP-A1
heterogeneous nuclear ribonucleoprotein A1
GO Process (7)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GSTP1
DFN7, FAEES3, GST3, GSTP, HEL-S-22, PI
glutathione S-transferase pi 1
GO Process (30)
GO Function (7)
GO Component (9)
Gene Ontology Biological Process
- cellular response to lipopolysaccharide [ISS]
- central nervous system development [TAS]
- common myeloid progenitor cell proliferation [ISS]
- glutathione derivative biosynthetic process [TAS]
- glutathione metabolic process [IDA]
- negative regulation of ERK1 and ERK2 cascade [IDA]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [ISS]
- negative regulation of JUN kinase activity [IDA]
- negative regulation of MAP kinase activity [IDA]
- negative regulation of MAPK cascade [NAS]
- negative regulation of acute inflammatory response [NAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of biosynthetic process [IDA]
- negative regulation of extrinsic apoptotic signaling pathway [IDA]
- negative regulation of fibroblast proliferation [ISS]
- negative regulation of interleukin-1 beta production [IDA]
- negative regulation of leukocyte proliferation [ISS]
- negative regulation of monocyte chemotactic protein-1 production [IDA]
- negative regulation of nitric-oxide synthase biosynthetic process [IDA]
- negative regulation of protein kinase activity [IDA]
- negative regulation of stress-activated MAPK cascade [ISS]
- negative regulation of tumor necrosis factor production [IDA]
- negative regulation of tumor necrosis factor-mediated signaling pathway [IC]
- nitric oxide storage [NAS]
- positive regulation of superoxide anion generation [ISS]
- regulation of ERK1 and ERK2 cascade [ISS]
- regulation of stress-activated MAPK cascade [ISS]
- response to reactive oxygen species [ISS]
- small molecule metabolic process [TAS]
- xenobiotic metabolic process [IDA, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling.
The increased cap-independent translation of anti-apoptotic proteins is involved in the development of drug resistance in lung cancer but signalling events regulating this are poorly understood. Fibroblast growth factor 2 (FGF-2) signalling-induced S6 kinase 2 (S6K2) activation is necessary, but the downstream mediator(s) coupling this kinase to the translational response is unknown. Here, we show that S6K2 binds and phosphorylates ... [more]
Nucleic Acids Res. Nov. 10, 2014; 42(20);12483-97 [Pubmed: 25324306]
Throughput
- High Throughput
Curated By
- BioGRID