HLTF
Gene Ontology Biological Process
Gene Ontology Molecular Function
ANXA2
Gene Ontology Biological Process
- angiogenesis [IMP]
- body fluid secretion [ISO]
- cellular response to acid chemical [IDA]
- collagen fibril organization [IMP]
- fibrinolysis [IMP]
- membrane budding [ISO]
- membrane raft assembly [ISO]
- negative regulation of catalytic activity [ISO]
- osteoclast development [ISO]
- positive regulation of binding [IMP]
- positive regulation of fibroblast proliferation [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of vesicle fusion [ISO]
- protein heterotetramerization [ISO]
- protein targeting to plasma membrane [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Schmidt-Lanterman incisure [IDA]
- cell cortex [ISO]
- cell junction [ISS]
- cell surface [ISO]
- cytoplasm [IDA, ISO]
- early endosome [IDA]
- endosome [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- extrinsic component of plasma membrane [IDA]
- late endosome membrane [ISO]
- lipid particle [ISO]
- lysosomal membrane [ISO]
- macropinosome [ISO]
- membrane [ISO, ISS]
- membrane raft [ISO]
- midbody [ISO]
- myelin sheath adaxonal region [IDA]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [ISO]
- protein complex [ISO]
- ruffle [ISO]
- sarcolemma [IDA]
- stress fiber [ISS]
- vesicle [ISO]
Co-crystal Structure
Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex.
Publication
SMARCA3, a chromatin-remodeling factor, is required for p11-dependent antidepressant action.
p11, through unknown mechanisms, is required for behavioral and cellular responses to selective serotonin reuptake inhibitors (SSRIs). We show that SMARCA3, a chromatin-remodeling factor, is a target for the p11/annexin A2 heterotetrameric complex. Determination of the crystal structure indicates that SMARCA3 peptide binds to a hydrophobic pocket in the heterotetramer. Formation of this complex increases the DNA-binding affinity of SMARCA3 ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HLTF ANXA2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| HLTF ANXA2 | Protein-peptide Protein-peptide An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments. | Low | - | BioGRID | - |
Curated By
- BioGRID