PRKCE
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- TRAM-dependent toll-like receptor 4 signaling pathway [ISS]
- activation of phospholipase C activity [TAS]
- apoptotic process [TAS]
- blood coagulation [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- lipopolysaccharide-mediated signaling pathway [ISS]
- negative regulation of sodium ion transmembrane transporter activity [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-serine phosphorylation [IDA]
- platelet activation [TAS]
- positive regulation of actin filament polymerization [ISS]
- positive regulation of cellular glucuronidation [IMP]
- positive regulation of cytokinesis [IMP]
- positive regulation of epithelial cell migration [IMP]
- positive regulation of fibroblast migration [ISS]
- positive regulation of wound healing [IMP]
- protein phosphorylation [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
BCL6
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [IDA]
- negative regulation of B cell apoptotic process [NAS]
- negative regulation of cell growth [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IMP, NAS]
- positive regulation of apoptotic process [IDA]
- protein import into nucleus, translocation [IGI]
- regulation of germinal center formation [NAS]
- regulation of immune response [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Interleukin-32α downregulates the activity of the B-cell CLL/lymphoma 6 protein by inhibiting protein kinase Cε-dependent SUMO-2 modification.
A proinflammatory cytokine IL-32 acts as an intracellular mediator. IL-32α interacts with many intracellular molecules, but there are no reports of interaction with a transcriptional repressor BCL6. In this study, we showed that PMA induces an interaction between IL-32α, PKCε, and BCL6, forming a trimer. To identify the mechanism of the interaction, we treated cells with various inhibitors. In HEK293 ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID