Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

The eukaryotic elongation factor eEF1A1 interacts with SAMHD1.

Morrissey C, Schwefel D, Ennis-Adeniran V, Taylor IA, Crow YJ, Webb M

Mutations in SAMHD1 cause Aicardi-Goutieres syndrome (AGS), a Mendelian inflammatory disease which displays remarkable clinical and biochemical overlap with congenital viral infection. SAMHD1 (SAM domain and HD domain-containing protein 1) has also been defined as an HIV-1 restriction-factor that, through a novel triphosphohydrolase activity, inhibits early stage HIV-1 replication in myeloid-derived dendritic cells (MDDCs), macrophages and resting CD4+ T-cells. The ... [more]

Biochem. J. Feb. 15, 2015; 466(1);69-76 [Pubmed: 25423367]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

SAMHD1

Gene Ontology Biological Process

Gene Ontology Molecular Function

RNA binding [IDA]dGTP binding [IDA]dGTPase activity [IDA]nucleic acid binding [IDA]protein binding [IPI]zinc ion binding [IDA]

Gene Ontology Cellular Component