BAIT
UBR5
DD5, EDD, EDD1, HYD
ubiquitin protein ligase E3 component n-recognin 5
GO Process (11)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- cell proliferation [TAS]
- cellular response to DNA damage stimulus [IDA, IMP]
- negative regulation of double-strand break repair [IMP]
- negative regulation of histone H2A K63-linked ubiquitination [IMP]
- positive regulation of canonical Wnt signaling pathway [IMP]
- positive regulation of catenin import into nucleus [IMP]
- positive regulation of protein import into nucleus, translocation [IMP]
- progesterone receptor signaling pathway [IDA]
- protein polyubiquitination [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA]
- ubiquitin-dependent protein catabolic process [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
MRS2
HPT, MRS2L
MRS2 magnesium transporter
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
EDD, a ubiquitin-protein ligase of the N-end rule pathway, associates with spindle assembly checkpoint components and regulates the mitotic response to nocodazole.
In this work, we identify physical and genetic interactions that implicate E3 identified by differential display (EDD) in promoting spindle assembly checkpoint (SAC) function. During mitosis, the SAC initiates a mitotic checkpoint in response to chromosomes with kinetochores unattached to spindle pole microtubules. Similar to Budding uninhibited by benzimidazoles-related 1 (BUBR1) siRNA, a bona fide SAC component, EDD siRNA abrogated ... [more]
J. Biol. Chem. May. 15, 2015; 290(20);12585-94 [Pubmed: 25833949]
Throughput
- High Throughput
Curated By
- BioGRID