BRCA1
Gene Ontology Biological Process
- DNA replication [IMP]
- G2 DNA damage checkpoint [ISO]
- cellular response to DNA damage stimulus [IMP]
- cellular response to indole-3-methanol [ISO]
- cellular response to tumor necrosis factor [ISO]
- centrosome cycle [IGI]
- centrosome duplication [TAS]
- chordate embryonic development [IMP]
- chromosome segregation [ISO]
- dosage compensation by inactivation of X chromosome [IDA]
- double-strand break repair [ISO]
- double-strand break repair via homologous recombination [IBA, ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage [ISO]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- negative regulation of fatty acid biosynthetic process [IBA, ISO]
- negative regulation of histone H3-K4 methylation [IMP]
- negative regulation of histone H3-K9 methylation [IMP, ISO]
- negative regulation of histone acetylation [IMP]
- negative regulation of reactive oxygen species metabolic process [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of DNA repair [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of cell cycle arrest [IBA, ISO]
- positive regulation of gene expression [ISO]
- positive regulation of histone H3-K4 methylation [IMP, ISO]
- positive regulation of histone H3-K9 acetylation [IMP, ISO]
- positive regulation of histone H3-K9 methylation [IMP]
- positive regulation of histone H4-K16 acetylation [IMP, ISO]
- positive regulation of histone H4-K20 methylation [IMP, ISO]
- positive regulation of histone acetylation [IMP, ISO]
- positive regulation of protein ubiquitination [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- positive regulation vascular endothelial growth factor production [ISO]
- postreplication repair [ISO]
- protein K6-linked ubiquitination [ISO]
- protein autoubiquitination [ISO]
- protein ubiquitination [IBA, ISO]
- regulation of DNA methylation [IMP]
- regulation of cell motility [IBA]
- regulation of cell proliferation [IBA]
- regulation of gene expression by genetic imprinting [IMP]
- response to estrogen [ISO]
- response to ionizing radiation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ACACA
Gene Ontology Biological Process
- acetyl-CoA metabolic process [IDA, ISO]
- cellular response to prostaglandin E stimulus [IDA]
- fatty acid biosynthetic process [IDA, ISO]
- lipid homeostasis [IMP]
- lipid metabolic process [IMP]
- multicellular organismal protein metabolic process [IMP]
- protein homotetramerization [IDA]
- response to organic cyclic compound [ISO]
- tissue homeostasis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
BRCA1 is a novel regulator of metabolic function in skeletal muscle.
Breast cancer type 1 (BRCA1) susceptibility protein is expressed across multiple tissues including skeletal muscle. The overall objective of this investigation was to define a functional role for BRCA1 in skeletal muscle using a translational approach. For the first time in both mice and humans, we identified the presence of multiple isoforms of BRCA1 in skeletal muscle. In response to ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID