PARP12
Gene Ontology Molecular Function
TICAM1
Gene Ontology Biological Process
- MyD88-independent toll-like receptor signaling pathway [IMP]
- apoptotic signaling pathway [IMP]
- defense response to virus [IMP]
- lipopolysaccharide-mediated signaling pathway [IMP]
- macrophage activation involved in immune response [IMP]
- positive regulation of B cell activation [IMP]
- positive regulation of B cell proliferation [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IGI, IMP, ISO]
- positive regulation of NF-kappaB transcription factor activity [IGI, IMP]
- positive regulation of chemokine biosynthetic process [IGI, IMP]
- positive regulation of interferon-beta biosynthetic process [IMP]
- positive regulation of interleukin-6 production [IMP]
- positive regulation of natural killer cell activation [IMP]
- positive regulation of nitric oxide biosynthetic process [IMP]
- positive regulation of protein binding [IDA]
- positive regulation of protein ubiquitination [IDA]
- positive regulation of tumor necrosis factor production [IDA, IGI, IMP]
- positive regulation of type I interferon production [IMP]
- regulation of protein homodimerization activity [IMP]
- response to exogenous dsRNA [IDA, IMP, ISO]
- response to lipopolysaccharide [IGI, IMP]
- signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
PARP12, an interferon-stimulated gene involved in the control of protein translation and inflammation.
Transcriptome analyses have recently identified PARP12, a member of a large family of ADP-ribosyl transferases, as an interferon-induced gene (ISG), whose function remains incompletely characterized. We demonstrate herein that PARP12 is a genuine ISG, whose expressed protein displays at least two distinct subcellular locations and related functions. Upon ectopic expression or exposure to oxidative stress, PARP12 is recruited to stress-granules ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID