BAIT
ABL1
AI325092, Abl, E430008G22Rik, c-Abl, RP23-65P13.3
c-abl oncogene 1, non-receptor tyrosine kinase
GO Process (57)
GO Function (18)
GO Component (16)
Gene Ontology Biological Process
- B cell proliferation [IMP]
- B cell proliferation involved in immune response [IGI, IMP]
- B cell receptor signaling pathway [IMP]
- B-1 B cell homeostasis [IMP]
- Bergmann glial cell differentiation [IGI]
- DNA damage induced protein phosphorylation [ISO]
- actin cytoskeleton organization [IDA]
- actin filament branching [IMP]
- activated T cell proliferation [IMP]
- alpha-beta T cell differentiation [IGI]
- cell migration [IBA]
- cellular response to DNA damage stimulus [ISO]
- cellular response to lipopolysaccharide [IMP]
- cerebellum morphogenesis [IGI]
- collateral sprouting [IMP]
- epidermal growth factor receptor signaling pathway [IGI]
- innate immune response [IBA]
- microspike assembly [IDA]
- negative regulation of BMP signaling pathway [IMP]
- negative regulation of ERK1 and ERK2 cascade [IMP]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- negative regulation of cell-cell adhesion [IGI]
- negative regulation of cellular senescence [IGI]
- negative regulation of endothelial cell apoptotic process [IGI]
- negative regulation of mitotic cell cycle [IDA, IGI]
- negative regulation of phospholipase C activity [ISO]
- negative regulation of protein serine/threonine kinase activity [ISO]
- negative regulation of ubiquitin-protein transferase activity [ISO]
- neuromuscular process controlling balance [IGI]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA, IGI, ISO]
- phagocytosis [IGI, IMP]
- platelet-derived growth factor receptor signaling pathway [IDA, IMP]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IGI]
- positive regulation of Wnt signaling pathway, planar cell polarity pathway [IGI]
- positive regulation of apoptotic process [IMP, ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of interferon-gamma secretion [IGI]
- positive regulation of interleukin-2 secretion [IGI]
- positive regulation of mitotic cell cycle [IGI]
- positive regulation of neuron death [IMP]
- positive regulation of osteoblast proliferation [IMP]
- positive regulation of oxidoreductase activity [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of release of sequestered calcium ion into cytosol [IGI]
- regulation of actin cytoskeleton organization [IGI]
- regulation of cell cycle [IDA]
- regulation of cellular senescence [IGI]
- regulation of extracellular matrix organization [IGI]
- regulation of response to DNA damage stimulus [ISO]
- response to oxidative stress [IMP, ISO]
- signal transduction in response to DNA damage [IBA, ISO]
- spleen development [IMP]
- substrate adhesion-dependent cell spreading [IDA]
- thymus development [IMP]
- transitional one stage B cell differentiation [IMP]
Gene Ontology Molecular Function- ATP binding [IDA, ISO]
- SH3 domain binding [ISO]
- actin filament binding [IDA]
- delta-catenin binding [ISO]
- kinase activity [IDA]
- magnesium ion binding [IDA, ISO]
- manganese ion binding [IDA, ISO]
- mitogen-activated protein kinase binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IBA, ISO]
- proline-rich region binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase activity [IDA, ISO]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [IDA, IGI, IMP, ISO]
- receptor binding [IBA]
- syntaxin binding [ISO]
- ATP binding [IDA, ISO]
- SH3 domain binding [ISO]
- actin filament binding [IDA]
- delta-catenin binding [ISO]
- kinase activity [IDA]
- magnesium ion binding [IDA, ISO]
- manganese ion binding [IDA, ISO]
- mitogen-activated protein kinase binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IBA, ISO]
- proline-rich region binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase activity [IDA, ISO]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [IDA, IGI, IMP, ISO]
- receptor binding [IBA]
- syntaxin binding [ISO]
Gene Ontology Cellular Component
- actin cytoskeleton [IDA]
- cell leading edge [IDA]
- cytoplasm [IDA, ISO]
- cytosol [ISA, ISO]
- endoplasmic reticulum [ISO]
- extrinsic component of cytoplasmic side of plasma membrane [IBA]
- growth cone [ISO]
- mitochondrion [ISO]
- neuron projection [ISO]
- neuronal cell body [ISO]
- nucleolus [ISO]
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [ISO]
- ruffle [ISO]
- synapse [ISO]
Mus musculus
PREY
PPARG
Nr1c3, PPAR-gamma, PPAR-gamma2, PPARgamma, PPARgamma2
peroxisome proliferator activated receptor gamma
GO Process (55)
GO Function (19)
GO Component (5)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- brown fat cell differentiation [IDA]
- cell fate commitment [IGI]
- cell maturation [ISO]
- cellular response to insulin stimulus [ISO]
- cellular response to lithium ion [IDA]
- cellular response to organic cyclic compound [IDA]
- epithelial cell differentiation [IGI]
- fat cell differentiation [IDA, IGI]
- fatty acid oxidation [ISO]
- glucose homeostasis [ISO]
- inflammatory response [TAS]
- intracellular receptor signaling pathway [TAS]
- lipoprotein transport [ISO]
- long-chain fatty acid transport [IMP]
- low-density lipoprotein particle receptor biosynthetic process [ISO]
- monocyte differentiation [ISO]
- negative regulation of acute inflammatory response [ISO]
- negative regulation of cell growth [ISO]
- negative regulation of cell proliferation [IMP, ISO]
- negative regulation of cellular response to insulin stimulus [IMP]
- negative regulation of cholesterol storage [ISO]
- negative regulation of collagen biosynthetic process [ISO]
- negative regulation of cytokine production [IMP]
- negative regulation of interferon-gamma-mediated signaling pathway [ISO]
- negative regulation of macrophage derived foam cell differentiation [ISO]
- negative regulation of pancreatic stellate cell proliferation [ISO]
- negative regulation of peptide hormone secretion [IMP]
- negative regulation of receptor biosynthetic process [ISO]
- negative regulation of sequestering of triglyceride [ISO]
- negative regulation of smooth muscle cell proliferation [ISO]
- negative regulation of telomerase activity [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- peroxisome proliferator activated receptor signaling pathway [ISO]
- placenta development [IMP]
- positive regulation of apoptotic process [ISO]
- positive regulation of fat cell differentiation [IDA, IGI, IMP, ISO]
- positive regulation of fatty acid oxidation [ISO]
- positive regulation of oligodendrocyte differentiation [ISO]
- positive regulation of phagocytosis, engulfment [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of blood pressure [ISO]
- regulation of fat cell differentiation [IDA, IGI, ISO]
- regulation of lipid metabolic process [ISO]
- regulation of transcription from RNA polymerase II promoter [ISO, TAS]
- regulation of transcription involved in cell fate commitment [IMP]
- response to lipid [IDA]
- response to low-density lipoprotein particle [ISO]
- response to retinoic acid [IDA, ISO]
- signal transduction [ISO]
- transcription from RNA polymerase II promoter [IDA]
- white fat cell differentiation [IDA]
Gene Ontology Molecular Function- DNA binding [IDA, IPI, ISO]
- RNA polymerase II regulatory region DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- WW domain binding [ISO]
- activating transcription factor binding [ISO]
- arachidonic acid binding [IDA]
- chromatin binding [IDA]
- drug binding [ISO]
- enzyme binding [ISO]
- estrogen receptor binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO, TAS]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA, ISO]
- protein binding [IPI]
- protein phosphatase binding [ISO]
- retinoid X receptor binding [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [IDA, ISO]
- DNA binding [IDA, IPI, ISO]
- RNA polymerase II regulatory region DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- WW domain binding [ISO]
- activating transcription factor binding [ISO]
- arachidonic acid binding [IDA]
- chromatin binding [IDA]
- drug binding [ISO]
- enzyme binding [ISO]
- estrogen receptor binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO, TAS]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA, ISO]
- protein binding [IPI]
- protein phosphatase binding [ISO]
- retinoid X receptor binding [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [IDA, ISO]
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
c-Abl tyrosine kinase promotes adipocyte differentiation by targeting PPAR-gamma 2.
Adipocyte differentiation, or adipogenesis, is a complex and highly regulated process. A recent proteomic analysis has predicted that the nonreceptor tyrosine kinase Abelson murine leukemia viral oncogene (c-Abl) is a putative key regulator of adipogenesis, but the underlying mechanism remained obscure. We found that c-Abl was activated during the early phase of mouse 3T3-L1 preadipocyte differentiation. Moreover, c-Abl activity was ... [more]
Proc. Natl. Acad. Sci. U.S.A. Nov. 18, 2014; 111(46);16365-70 [Pubmed: 25368164]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PPARG ABL1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID