TSPO
Gene Ontology Biological Process
- behavioral response to pain [ISO]
- chloride transport [ISO]
- contact inhibition [ISO]
- glial cell migration [ISO]
- ion transport [ISO]
- negative regulation of glial cell proliferation [ISO]
- negative regulation of nitric oxide biosynthetic process [ISO]
- negative regulation of tumor necrosis factor production [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of calcium ion transport [ISO]
- positive regulation of glial cell proliferation [ISO]
- positive regulation of mitochondrial depolarization [ISO]
- positive regulation of necrotic cell death [ISO]
- positive regulation of reactive oxygen species metabolic process [ISO]
- regulation of steroid biosynthetic process [ISO]
- signal transduction [ISO]
- steroid biosynthetic process [ISO]
- synaptic transmission [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
VDAC1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control.
The 18-kDa TSPO (translocator protein) localizes on the outer mitochondrial membrane (OMM) and participates in cholesterol transport. Here, we report that TSPO inhibits mitochondrial autophagy downstream of the PINK1-PARK2 pathway, preventing essential ubiquitination of proteins. TSPO abolishes mitochondrial relocation of SQSTM1/p62 (sequestosome 1), and consequently that of the autophagic marker LC3 (microtubule-associated protein 1 light chain 3), thus leading to ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID