PDGFRB
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- G-protein coupled receptor signaling pathway [TAS]
- aorta morphogenesis [ISS]
- cardiac myofibril assembly [ISS]
- cell chemotaxis [IDA]
- cell migration [IMP]
- cell migration involved in coronary angiogenesis [ISS]
- cell migration involved in vasculogenesis [ISS]
- cellular response to platelet-derived growth factor stimulus [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- metanephric glomerular capillary formation [ISS]
- metanephric glomerular mesangial cell proliferation involved in metanephros development [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine phosphorylation [IDA]
- phosphatidylinositol metabolic process [IMP]
- phosphatidylinositol-mediated signaling [IMP, TAS]
- platelet-derived growth factor receptor signaling pathway [IDA]
- platelet-derived growth factor receptor-beta signaling pathway [IMP]
- positive regulation of DNA biosynthetic process [ISS]
- positive regulation of ERK1 and ERK2 cascade [IMP, ISS]
- positive regulation of MAP kinase activity [ISS]
- positive regulation of calcium ion import [ISS]
- positive regulation of cell migration [IDA]
- positive regulation of cell proliferation [IMP]
- positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [IDA]
- positive regulation of chemotaxis [ISS]
- positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway [ISS]
- positive regulation of mitosis [ISS]
- positive regulation of phosphatidylinositol 3-kinase activity [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISS]
- positive regulation of phospholipase C activity [IDA]
- positive regulation of phosphoprotein phosphatase activity [IDA]
- positive regulation of reactive oxygen species metabolic process [ISS]
- positive regulation of smooth muscle cell migration [IMP, ISS]
- positive regulation of smooth muscle cell proliferation [IMP, ISS]
- protein autophosphorylation [IDA]
- regulation of actin cytoskeleton organization [ISS]
- retina vasculature development in camera-type eye [ISS]
- signal transduction [IDA]
- smooth muscle cell chemotaxis [ISS]
Gene Ontology Molecular Function- platelet activating factor receptor activity [TAS]
- platelet-derived growth factor beta-receptor activity [IDA, IMP]
- platelet-derived growth factor binding [IDA, IPI]
- platelet-derived growth factor receptor binding [IPI]
- platelet-derived growth factor-activated receptor activity [TAS]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein tyrosine kinase activity [IDA]
- receptor binding [IPI]
- vascular endothelial growth factor binding [IPI]
- platelet activating factor receptor activity [TAS]
- platelet-derived growth factor beta-receptor activity [IDA, IMP]
- platelet-derived growth factor binding [IDA, IPI]
- platelet-derived growth factor receptor binding [IPI]
- platelet-derived growth factor-activated receptor activity [TAS]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein tyrosine kinase activity [IDA]
- receptor binding [IPI]
- vascular endothelial growth factor binding [IPI]
Gene Ontology Cellular Component
TNK2
Gene Ontology Biological Process
- cell differentiation [IBA]
- cell migration [IBA]
- cell surface receptor signaling pathway [TAS]
- innate immune response [IBA]
- negative regulation of catalytic activity [TAS]
- peptidyl-tyrosine autophosphorylation [IBA]
- phosphorylation [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- regulation of cell proliferation [IBA]
- regulation of clathrin-mediated endocytosis [IDA]
- small GTPase mediated signal transduction [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function- GTPase inhibitor activity [TAS]
- WW domain binding [ISS]
- epidermal growth factor receptor binding [IDA]
- hormone receptor binding [IBA]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- protein binding [IPI]
- protein serine/threonine/tyrosine kinase activity [IDA]
- protein tyrosine kinase activity [IDA]
- GTPase inhibitor activity [TAS]
- WW domain binding [ISS]
- epidermal growth factor receptor binding [IDA]
- hormone receptor binding [IBA]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- protein binding [IPI]
- protein serine/threonine/tyrosine kinase activity [IDA]
- protein tyrosine kinase activity [IDA]
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
PDGFR-β-activated ACK1-AKT signaling promotes glioma tumorigenesis.
Aberrant PDGF-PDGFR signaling and its effects on downstream effectors have been implicated in glioma development. A crucial AKT regulator, ACK1 (TNK2) has been shown to be a downstream mediator of PDGF signaling; however, the exact underlying mechanisms in gliomas remain elusive. Here, we report that in glioma cells, PDGFR-β activation enhanced the interaction between ACK1 and AKT, resulting in AKT ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TNK2 PDGFRB | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| TNK2 PDGFRB | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID