ITGA3
Gene Ontology Biological Process
- cell adhesion [ISO]
- dendritic spine maintenance [IGI, IMP]
- exploration behavior [IGI]
- fusion of sperm to egg plasma membrane [IMP]
- lung development [ISO]
- memory [IMP]
- negative regulation of Rho protein signal transduction [IGI]
- negative regulation of cell projection organization [ISO]
- nephron development [ISO]
- neuron migration [IMP]
- positive regulation of cell-substrate adhesion [ISO]
- positive regulation of epithelial cell migration [ISO]
- positive regulation of establishment of protein localization to plasma membrane [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of neuron projection development [ISO]
- regulation of BMP signaling pathway [ISO]
- regulation of Wnt signaling pathway [ISO]
- regulation of transforming growth factor beta receptor signaling pathway [ISO]
- renal filtration [ISO]
- single-organism behavior [IMP]
- skin development [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- basolateral plasma membrane [IDA]
- cell periphery [ISO]
- cell surface [ISO]
- excitatory synapse [IDA]
- external side of plasma membrane [IDA]
- extracellular vesicular exosome [ISO]
- filopodium membrane [ISO]
- focal adhesion [ISO]
- growth cone [ISO]
- integrin alpha3-beta1 complex [ISO]
- invadopodium membrane [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- receptor complex [ISO]
- synapse [IDA]
- synaptic membrane [IDA]
ITGB4
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Integrin α3β1 regulates kidney collecting duct development via TRAF6-dependent K63-linked polyubiquitination of Akt.
The collecting system of the kidney develops from the ureteric bud (UB), which undergoes branching morphogenesis, a process regulated by multiple factors, including integrin-extracellular matrix interactions. The laminin (LM)-binding integrin α3β1 is crucial for this developmental program; however, the LM types and LM/integrin α3β1-dependent signaling pathways are poorly defined. We show that α3 chain-containing LMs promote normal UB branching morphogenesis ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID