SYVN1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PPARGC1B
Gene Ontology Biological Process
- actin filament organization [IMP]
- bone trabecula formation [IMP]
- cellular response to reactive oxygen species [IDA]
- intracellular estrogen receptor signaling pathway [ISO]
- negative regulation of transcription, DNA-templated [IMP]
- ossification [IMP]
- positive regulation of alkaline phosphatase activity [IMP]
- positive regulation of bone resorption [IMP]
- positive regulation of osteoclast differentiation [IMP]
- positive regulation of phosphorylation [IMP]
- positive regulation of receptor activity [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [IBA]
- positive regulation of transcription from RNA polymerase II promoter [IBA, ISO]
- positive regulation of transcription, DNA-templated [IMP]
- regulation of transcription, DNA-templated [ISO]
- transcription from RNA polymerase II promoter [IBA, ISO]
- transcription from mitochondrial promoter [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC-1β.
Obesity is a major global public health problem, and understanding its pathogenesis is critical for identifying a cure. In this study, a gene knockout strategy was used in post-neonatal mice to delete synoviolin (Syvn)1/Hrd1/Der3, an ER-resident E3 ubiquitin ligase with known roles in homeostasis maintenance. Syvn1 deficiency resulted in weight loss and lower accumulation of white adipose tissue in otherwise ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SYVN1 PPARGC1B | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 1256247 | |
| SYVN1 PPARGC1B | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | Low | - | BioGRID | - | |
| SYVN1 PPARGC1B | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID