AMBRA1
Gene Ontology Biological Process
Gene Ontology Molecular Function
HSPD1
Gene Ontology Biological Process
- 'de novo' protein folding [ISS]
- ATP catabolic process [ISS]
- B cell activation [IDA]
- B cell cytokine production [IDA]
- B cell proliferation [IDA]
- MyD88-dependent toll-like receptor signaling pathway [IDA]
- T cell activation [IDA]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- chaperone-mediated protein complex assembly [ISS]
- isotype switching to IgG isotypes [IDA]
- negative regulation of apoptotic process [IMP]
- positive regulation of T cell activation [IDA, ISS]
- positive regulation of T cell mediated immune response to tumor cell [IDA]
- positive regulation of apoptotic process [IMP]
- positive regulation of interferon-alpha production [IDA]
- positive regulation of interferon-gamma production [IDA, ISS]
- positive regulation of interleukin-10 production [IDA]
- positive regulation of interleukin-12 production [IDA]
- positive regulation of interleukin-6 production [IDA]
- positive regulation of macrophage activation [IDA]
- protein maturation [ISS]
- protein refolding [IDA]
- protein stabilization [IMP, ISS]
- response to unfolded protein [IDA]
Gene Ontology Molecular Function- ATPase activity [ISS]
- DNA replication origin binding [ISS]
- chaperone binding [IPI]
- double-stranded RNA binding [IDA]
- lipopolysaccharide binding [IDA]
- p53 binding [IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- single-stranded DNA binding [ISS]
- ubiquitin protein ligase binding [IPI]
- unfolded protein binding [IC, ISS]
- ATPase activity [ISS]
- DNA replication origin binding [ISS]
- chaperone binding [IPI]
- double-stranded RNA binding [IDA]
- lipopolysaccharide binding [IDA]
- p53 binding [IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- single-stranded DNA binding [ISS]
- ubiquitin protein ligase binding [IPI]
- unfolded protein binding [IC, ISS]
Gene Ontology Cellular Component
- cell surface [IDA]
- coated pit [IDA]
- coated vesicle [IDA]
- cyclin-dependent protein kinase activating kinase holoenzyme complex [IDA]
- cytoplasm [IDA]
- cytosol [IDA]
- early endosome [IDA]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- lipopolysaccharide receptor complex [IDA]
- membrane [IDA]
- mitochondrial inner membrane [ISS]
- mitochondrial matrix [TAS]
- mitochondrion [IDA]
- protein complex [IDA]
- secretory granule [ISS]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
AMBRA1 interplay with cullin E3 ubiquitin ligases regulates autophagy dynamics.
Autophagy maintains cellular homeostasis by degrading harmful or unnecessary intracellular components. How the autophagy response is induced rapidly and transiently remains largely unknown. We report that the E3 ubiquitin ligases Cullin-5 and Cullin-4 regulate the onset and termination of autophagy, respectively, by dynamically interacting with AMBRA1, a regulator of autophagy. Under normal conditions, Cullin-4 binding to AMBRA1 limits its protein ... [more]
Throughput
- High Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
AMBRA1 HSPD1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID