BAIT
UNK
B230379M23Rik, Zc3h5, Zc3hdc5, mKIAA1753, RP23-42F6.4
unkempt homolog (Drosophila)
GO Process (0)
GO Function (0)
GO Component (0)
Mus musculus
PREY
PTPRF
AA591035, LAR, LARS, RPTP-LAR, RP23-94L18.2
protein tyrosine phosphatase, receptor type, F
GO Process (20)
GO Function (8)
GO Component (9)
Gene Ontology Biological Process
- cell migration [ISO]
- homophilic cell adhesion via plasma membrane adhesion molecules [ISO]
- negative regulation of cell projection organization [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of cytokine-mediated signaling pathway [ISO]
- negative regulation of epidermal growth factor receptor signaling pathway [ISO]
- negative regulation of insulin receptor signaling pathway [ISO]
- negative regulation of neurotrophin TRK receptor signaling pathway [ISO]
- negative regulation of receptor binding [ISO]
- nervous system development [ISO]
- neuron projection regeneration [IMP]
- peptidyl-tyrosine dephosphorylation [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of dendrite morphogenesis [ISO]
- positive regulation of neuron apoptotic process [ISO]
- protein dephosphorylation [ISO]
- regulation of axon regeneration [IMP]
- regulation of neuron projection development [IMP]
- regulation of synapse structure or activity [ISO]
- signal transduction [ISO]
Gene Ontology Molecular Function- chondroitin sulfate proteoglycan binding [IPI]
- insulin receptor binding [ISO]
- phosphate ion binding [ISO]
- phosphoprotein phosphatase activity [ISO]
- protein complex binding [IDA]
- protein tyrosine phosphatase activity [ISO]
- receptor tyrosine kinase binding [ISO]
- transmembrane receptor protein tyrosine phosphatase activity [ISO]
- chondroitin sulfate proteoglycan binding [IPI]
- insulin receptor binding [ISO]
- phosphate ion binding [ISO]
- phosphoprotein phosphatase activity [ISO]
- protein complex binding [IDA]
- protein tyrosine phosphatase activity [ISO]
- receptor tyrosine kinase binding [ISO]
- transmembrane receptor protein tyrosine phosphatase activity [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt.
Cellular morphology is an essential determinant of cellular function in all kingdoms of life, yet little is known about how cell shape is controlled. Here we describe a molecular program that controls the early morphology of neurons through a metazoan-specific zinc finger protein, Unkempt. Depletion of Unkempt in mouse embryos disrupts the shape of migrating neurons, while ectopic expression confers ... [more]
Genes Dev. Mar. 01, 2015; 29(5);501-12 [Pubmed: 25737280]
Throughput
- High Throughput
Curated By
- BioGRID