DPB11
Gene Ontology Biological Process
- DNA replication checkpoint [IMP]
- DNA replication initiation [IMP]
- double-strand break repair via break-induced replication [IMP]
- lagging strand elongation [TAS]
- leading strand elongation [TAS]
- mating type switching [IMP]
- mismatch repair [NAS]
- mitotic G2 DNA damage checkpoint [IGI]
- nucleotide-excision repair [TAS]
- positive regulation of protein phosphorylation [IDA]
- recombinational repair [IDA, IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NHP10
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Ino80 complex [IDA, IPI]
- nucleus [IDA]
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
Chromatin remodeling factors Isw2 and Ino80 regulate checkpoint activity and chromatin structure in S phase.
When cells undergo replication stress, proper checkpoint activation and deactivation are critical for genomic stability and cell survival and therefore must be highly regulated. Although mechanisms of checkpoint activation are well studied, mechanisms of checkpoint deactivation are far less understood. Previously, we reported that chromatin remodeling factors Isw2 and Ino80 attenuate the S-phase checkpoint activity in Saccharomyces cerevisiae, especially during ... [more]
Throughput
- Low Throughput
Ontology Terms
- resistance to chemicals (APO:0000087)
- vegetative growth (APO:0000106)
Additional Notes
- Figure 2
- dpb11-1 isw2 nhp10 triple mutant shows increased MMS sensitivity
- genetic complex
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DPB11 NHP10 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.143 | BioGRID | 1992955 | |
| DPB11 NHP10 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 1256932 | |
| DPB11 NHP10 | Positive Genetic Positive Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a less severe fitness defect than expected under a given condition. This term is reserved for high or low throughput studies with scores. | High | 2.681 | BioGRID | 227250 |
Curated By
- BioGRID