BAIT

AUTS2

FBRSL2, MRD26
autism susceptibility candidate 2
Autism spectrum disorder (ASD) Project
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY

TLE3

ESG, ESG3, GRG3, HsT18976
transducin-like enhancer of split 3
Autism spectrum disorder (ASD) Project
UPS Project
GO Process (3)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

An AUTS2-Polycomb complex activates gene expression in the CNS.

Gao Z, Lee P, Stafford JM, von Schimmelmann M, Schaefer A, Reinberg D

Naturally occurring variations of Polycomb repressive complex 1 (PRC1) comprise a core assembly of Polycomb group proteins and additional factors that include, surprisingly, autism susceptibility candidate 2 (AUTS2). Although AUTS2 is often disrupted in patients with neuronal disorders, the mechanism underlying the pathogenesis is unclear. We investigated the role of AUTS2 as part of a previously identified PRC1 complex (PRC1-AUTS2), ... [more]

Nature Dec. 18, 2014; 516(7531);349-54 [Pubmed: 25519132]

Throughput

  • High Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
TLE3 AUTS2
Proximity Label-MS
Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

High-BioGRID
3571318

Curated By

  • BioGRID