BAIT
SPAC4F10.03C
tRNA 2'-O-ribose methyltransferase (predicted)
GO Process (2)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Schizosaccharomyces pombe (972h)
PREY
SPATRNAPHE.01
tRNA
GO Process (1)
GO Function (0)
GO Component (0)
Gene Ontology Biological Process
Schizosaccharomyces pombe (972h)
Dosage Rescue
A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.
Publication
Conservation of an intricate circuit for crucial modifications of the tRNAPhe anticodon loop in eukaryotes.
Post-transcriptional tRNA modifications are critical for efficient and accurate translation, and have multiple different roles. Lack of modifications often leads to different biological consequences in different organisms, and in humans is frequently associated with neurological disorders. We investigate here the conservation of a unique circuitry for anticodon loop modification required for healthy growth in the yeast Saccharomyces cerevisiae. S. cerevisiae ... [more]
RNA Jan. 01, 2015; 21(1);61-74 [Pubmed: 25404562]
Throughput
- Low Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
Additional Notes
- Figure 3
- Overexpression of tRNA(Phe) suppresses growth defect of trm7 mutant
Curated By
- BioGRID