BAIT

YJU3

L000002514, YKL094W
Monoglyceride lipase (MGL); functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family
GO Process (1)
GO Function (2)
GO Component (5)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)
PREY

ROG1

putative lipase ROG1, YGL144C
Protein with putative serine active lipase domain; ROG1 has a paralog, YDL109C, that arose from the whole genome duplication
GO Process (1)
GO Function (1)
GO Component (0)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Saccharomyces cerevisiae (S288c)

Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

ROG1 encodes a monoacylglycerol lipase in Saccharomyces cerevisiae.

Vishnu Varthini L, Selvaraju K, Srinivasan M, Nachiappan V

Lipid metabolism is extensively studied in Saccharomyces cerevisiae. Here, we report that revertant of glycogen synthase kinase mutation-1 (Rog1p) possesses monoacylglycerol (MAG) lipase activity in S. cerevisiae. The lipase activity of Rog1p was confirmed in two ways: through analysis of a strain with a double deletion of ROG1 and monoglyceride lipase YJU3 (yju3Δrog1Δ) and by site-directed mutagenesis of the ROG1 ... [more]

FEBS Lett. Jan. 02, 2015; 589(1);23-30 [Pubmed: 25433290]

Throughput

  • Low Throughput

Ontology Terms

  • protein activity (APO:0000022)

Additional Notes

  • Figure 3
  • double mutant yju3 rog1 has reduced MAG lipase activity

Curated By

  • BioGRID