BAIT
NEURL1
NEUR1, NEURL, RNF67, bA416N2.1, neu, neu-1
neuralized E3 ubiquitin protein ligase 1
GO Process (10)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- cellular response to amino acid stimulus [ISS]
- negative regulation of Notch signaling pathway [IDA]
- negative regulation of cell proliferation [IDA]
- nervous system development [TAS]
- positive regulation of apoptotic process [IDA]
- positive regulation of dendritic spine development [ISS]
- positive regulation of filopodium assembly [ISS]
- positive regulation of long-term neuronal synaptic plasticity [ISS]
- positive regulation of synapse maturation [ISS]
- protein monoubiquitination [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ARFIP2
POR1
ADP-ribosylation factor interacting protein 2
GO Process (5)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Panorama of ancient metazoan macromolecular complexes
Macromolecular complexes are essential to conserved biological processes, but their prevalence across animals is unclear. By combining extensive biochemical fractionation with quantitative mass spectrometry, here we directly examined the composition of soluble multiprotein complexes among diverse metazoan models. Using an integrative approach, we generated a draft conservation map consisting of more than one million putative high-confidence co-complex interactions for species ... [more]
Nature Sep. 17, 2015; 525(7569);339-44 [Pubmed: 26344197]
Quantitative Score
- 0.07286049 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- Fractionation was combined with mass spectrometry from five diverse animal species to predict co-complex protein interactions conserved across metazoa using an integrative computational scoring procedure along with an SVM approach. The significant data set of 16655 PPI, was derived from a set of more than 1M interactions by examining a ROC curve of predicted interactions against reference annotated complexes at a 67.5% cumulative precision.
Curated By
- BioGRID