BAIT
NCKAP1L
HEM1
NCK-associated protein 1-like
GO Process (31)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- B cell homeostasis [ISS]
- B cell receptor signaling pathway [IMP]
- T cell homeostasis [ISS]
- actin polymerization-dependent cell motility [IMP]
- chemotaxis [IDA]
- cortical actin cytoskeleton organization [IMP]
- erythrocyte development [IEP]
- maintenance of cell polarity [IMP]
- myeloid cell homeostasis [ISS]
- negative regulation of apoptotic process [IMP]
- negative regulation of interleukin-17 production [ISS]
- negative regulation of interleukin-6 production [ISS]
- negative regulation of myosin-light-chain-phosphatase activity [IMP]
- neutrophil chemotaxis [IDA]
- positive regulation of B cell differentiation [ISS]
- positive regulation of B cell proliferation [IMP]
- positive regulation of CD4-positive, alpha-beta T cell differentiation [ISS]
- positive regulation of CD8-positive, alpha-beta T cell differentiation [ISS]
- positive regulation of Rac GTPase activity [IMP]
- positive regulation of T cell proliferation [ISS]
- positive regulation of actin filament polymerization [IMP]
- positive regulation of cell adhesion mediated by integrin [ISS]
- positive regulation of erythrocyte differentiation [ISS]
- positive regulation of gamma-delta T cell differentiation [ISS]
- positive regulation of lymphocyte differentiation [ISS]
- positive regulation of neutrophil chemotaxis [ISS]
- positive regulation of phagocytosis, engulfment [ISS]
- positive regulation of phosphorylation [IMP]
- positive regulation of protein kinase activity [IMP]
- protein complex assembly [ISS]
- response to drug [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CYFIP1
P140SRA-1, SHYC, SRA-1, SRA1
cytoplasmic FMR1 interacting protein 1
GO Process (6)
GO Function (4)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Panorama of ancient metazoan macromolecular complexes
Macromolecular complexes are essential to conserved biological processes, but their prevalence across animals is unclear. By combining extensive biochemical fractionation with quantitative mass spectrometry, here we directly examined the composition of soluble multiprotein complexes among diverse metazoan models. Using an integrative approach, we generated a draft conservation map consisting of more than one million putative high-confidence co-complex interactions for species ... [more]
Nature Sep. 17, 2015; 525(7569);339-44 [Pubmed: 26344197]
Quantitative Score
- 1.0 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- Fractionation was combined with mass spectrometry from five diverse animal species to predict co-complex protein interactions conserved across metazoa using an integrative computational scoring procedure along with an SVM approach. The significant data set of 16655 PPI, was derived from a set of more than 1M interactions by examining a ROC curve of predicted interactions against reference annotated complexes at a 67.5% cumulative precision.
Curated By
- BioGRID