BAIT
DIS3
2810028N01Rik, EXOSC11, KIAA1008, RRP44, dis3p, RP11-342J4.3
DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
GO Process (11)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- CUT catabolic process [IMP]
- RNA metabolic process [TAS]
- RNA phosphodiester bond hydrolysis, exonucleolytic [IMP]
- exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [TAS]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [TAS]
- nucleic acid phosphodiester bond hydrolysis [IMP]
- positive regulation of GTPase activity [IDA]
- rRNA catabolic process [IMP]
- rRNA processing [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GNAS
AHO, C20orf45, GNAS1, GPSA, GSA, GSP, NESP, PHP1A, PHP1B, PHP1C, POH, RP4-543J19.4
GNAS complex locus
GO Process (29)
GO Function (11)
GO Component (10)
Gene Ontology Biological Process
- activation of adenylate cyclase activity [TAS]
- adenylate cyclase-activating G-protein coupled receptor signaling pathway [IDA, IMP]
- adenylate cyclase-activating adrenergic receptor signaling pathway [IDA]
- adenylate cyclase-activating dopamine receptor signaling pathway [IBA, ISS]
- blood coagulation [TAS]
- bone development [IDA, IMP]
- cAMP biosynthetic process [TAS]
- cellular response to catecholamine stimulus [ISS]
- cellular response to glucagon stimulus [TAS]
- cellular response to prostaglandin E stimulus [ISS]
- cognition [IDA, IMP]
- developmental growth [IDA, IMP]
- energy reserve metabolic process [TAS]
- female pregnancy [NAS]
- hair follicle placode formation [IDA, IMP]
- intracellular transport [NAS]
- negative regulation of multicellular organism growth [ISS]
- platelet aggregation [IDA, IMP]
- positive regulation of Ras GTPase activity [IDA]
- positive regulation of cAMP biosynthetic process [IDA]
- positive regulation of cAMP-mediated signaling [IDA]
- protein secretion [NAS]
- regulation of insulin secretion [TAS]
- response to parathyroid hormone [IMP]
- sensory perception of chemical stimulus [IBA]
- sensory perception of smell [TAS]
- small molecule metabolic process [TAS]
- transmembrane transport [TAS]
- water transport [TAS]
Gene Ontology Molecular Function- D1 dopamine receptor binding [IBA]
- G-protein beta/gamma-subunit complex binding [IBA]
- GTPase activity [IBA, TAS]
- adenylate cyclase activity [TAS]
- beta-2 adrenergic receptor binding [IBA]
- corticotropin-releasing hormone receptor 1 binding [IBA]
- insulin-like growth factor receptor binding [IBA]
- ionotropic glutamate receptor binding [IBA]
- mu-type opioid receptor binding [IBA]
- protein binding [IPI]
- signal transducer activity [IBA, IDA]
- D1 dopamine receptor binding [IBA]
- G-protein beta/gamma-subunit complex binding [IBA]
- GTPase activity [IBA, TAS]
- adenylate cyclase activity [TAS]
- beta-2 adrenergic receptor binding [IBA]
- corticotropin-releasing hormone receptor 1 binding [IBA]
- insulin-like growth factor receptor binding [IBA]
- ionotropic glutamate receptor binding [IBA]
- mu-type opioid receptor binding [IBA]
- protein binding [IPI]
- signal transducer activity [IBA, IDA]
Gene Ontology Cellular Component
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Panorama of ancient metazoan macromolecular complexes
Macromolecular complexes are essential to conserved biological processes, but their prevalence across animals is unclear. By combining extensive biochemical fractionation with quantitative mass spectrometry, here we directly examined the composition of soluble multiprotein complexes among diverse metazoan models. Using an integrative approach, we generated a draft conservation map consisting of more than one million putative high-confidence co-complex interactions for species ... [more]
Nature Sep. 17, 2015; 525(7569);339-44 [Pubmed: 26344197]
Quantitative Score
- 0.079492524 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- Fractionation was combined with mass spectrometry from five diverse animal species to predict co-complex protein interactions conserved across metazoa using an integrative computational scoring procedure along with an SVM approach. The significant data set of 16655 PPI, was derived from a set of more than 1M interactions by examining a ROC curve of predicted interactions against reference annotated complexes at a 67.5% cumulative precision.
Curated By
- BioGRID