BAIT
ASNS
ASNSD, TS11
asparagine synthetase (glutamine-hydrolyzing)
GO Process (10)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
- activation of signaling protein activity involved in unfolded protein response [TAS]
- asparagine biosynthetic process [IC, IDA]
- cellular amino acid biosynthetic process [TAS]
- cellular nitrogen compound metabolic process [TAS]
- cellular protein metabolic process [TAS]
- cellular response to glucose starvation [IDA]
- endoplasmic reticulum unfolded protein response [TAS]
- negative regulation of apoptotic process [IMP]
- positive regulation of mitotic cell cycle [IDA]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
HSPBP1
FES1, PP1845
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
GO Process (4)
GO Function (2)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Panorama of ancient metazoan macromolecular complexes
Macromolecular complexes are essential to conserved biological processes, but their prevalence across animals is unclear. By combining extensive biochemical fractionation with quantitative mass spectrometry, here we directly examined the composition of soluble multiprotein complexes among diverse metazoan models. Using an integrative approach, we generated a draft conservation map consisting of more than one million putative high-confidence co-complex interactions for species ... [more]
Nature Sep. 17, 2015; 525(7569);339-44 [Pubmed: 26344197]
Quantitative Score
- 0.085100312 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- Fractionation was combined with mass spectrometry from five diverse animal species to predict co-complex protein interactions conserved across metazoa using an integrative computational scoring procedure along with an SVM approach. The significant data set of 16655 PPI, was derived from a set of more than 1M interactions by examining a ROC curve of predicted interactions against reference annotated complexes at a 67.5% cumulative precision.
Curated By
- BioGRID