BAIT
GNB2L1
Gnb2-rs1, H12.3, HLC-7, PIG21, RACK1, HLC7
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GO Process (24)
GO Function (13)
GO Component (11)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- negative regulation of Wnt signaling pathway [ISS]
- negative regulation of cell growth [IDA]
- negative regulation of gene expression [IMP]
- negative regulation of hydrogen peroxide-induced neuron death [IGI]
- negative regulation of phagocytosis [IMP]
- negative regulation of protein kinase B signaling [IMP]
- negative regulation of protein tyrosine kinase activity [IDA]
- negative regulation of translation [ISS]
- positive regulation of GTPase activity [IDA]
- positive regulation of apoptotic process [IDA, IMP]
- positive regulation of cAMP catabolic process [IMP]
- positive regulation of cell migration [IDA]
- positive regulation of cyclic-nucleotide phosphodiesterase activity [IMP]
- positive regulation of gastrulation [ISS]
- positive regulation of intrinsic apoptotic signaling pathway [IMP]
- positive regulation of mitochondrial depolarization [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA]
- positive regulation of protein homooligomerization [IDA, IMP]
- positive regulation of protein phosphorylation [IDA]
- regulation of cell cycle [IDA]
- regulation of cell division [ISS]
- regulation of establishment of cell polarity [ISS]
- regulation of protein localization [ISS]
Gene Ontology Molecular Function- SH2 domain binding [IDA]
- cysteine-type endopeptidase activator activity involved in apoptotic process [IMP]
- enzyme binding [IPI]
- ion channel inhibitor activity [ISS]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein complex scaffold [TAS]
- protein homodimerization activity [IDA]
- protein kinase C binding [IDA]
- protein phosphatase binding [IPI]
- protein tyrosine kinase inhibitor activity [IDA]
- receptor binding [NAS]
- receptor tyrosine kinase binding [IDA]
- SH2 domain binding [IDA]
- cysteine-type endopeptidase activator activity involved in apoptotic process [IMP]
- enzyme binding [IPI]
- ion channel inhibitor activity [ISS]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein complex scaffold [TAS]
- protein homodimerization activity [IDA]
- protein kinase C binding [IDA]
- protein phosphatase binding [IPI]
- protein tyrosine kinase inhibitor activity [IDA]
- receptor binding [NAS]
- receptor tyrosine kinase binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
LSM12
PNAS-135
LSM12 homolog (S. cerevisiae)
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Panorama of ancient metazoan macromolecular complexes
Macromolecular complexes are essential to conserved biological processes, but their prevalence across animals is unclear. By combining extensive biochemical fractionation with quantitative mass spectrometry, here we directly examined the composition of soluble multiprotein complexes among diverse metazoan models. Using an integrative approach, we generated a draft conservation map consisting of more than one million putative high-confidence co-complex interactions for species ... [more]
Nature Sep. 17, 2015; 525(7569);339-44 [Pubmed: 26344197]
Quantitative Score
- 0.079737852 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- Fractionation was combined with mass spectrometry from five diverse animal species to predict co-complex protein interactions conserved across metazoa using an integrative computational scoring procedure along with an SVM approach. The significant data set of 16655 PPI, was derived from a set of more than 1M interactions by examining a ROC curve of predicted interactions against reference annotated complexes at a 67.5% cumulative precision.
Curated By
- BioGRID