BAIT
UBA6
E1-L2, MOP-4, UBE1L2
ubiquitin-like modifier activating enzyme 6
GO Process (2)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
MTRR
MSR, cblE
5-methyltetrahydrofolate-homocysteine methyltransferase reductase
GO Process (12)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- DNA methylation [ISS]
- cellular nitrogen compound metabolic process [TAS]
- cobalamin metabolic process [TAS]
- folic acid metabolic process [ISS]
- methionine metabolic process [TAS]
- methylation [TAS]
- oxidation-reduction process [TAS]
- small molecule metabolic process [TAS]
- sulfur amino acid metabolic process [TAS]
- vitamin metabolic process [TAS]
- water-soluble vitamin metabolic process [TAS]
- xenobiotic metabolic process [TAS]
Gene Ontology Molecular Function- FMN binding [TAS]
- NADP binding [TAS]
- NADPH-hemoprotein reductase activity [IBA]
- [methionine synthase] reductase activity [TAS]
- flavin adenine dinucleotide binding [IDA, TAS]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [IBA]
- oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [IDA]
- FMN binding [TAS]
- NADP binding [TAS]
- NADPH-hemoprotein reductase activity [IBA]
- [methionine synthase] reductase activity [TAS]
- flavin adenine dinucleotide binding [IDA, TAS]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [IBA]
- oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [IDA]
Gene Ontology Cellular Component
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Panorama of ancient metazoan macromolecular complexes
Macromolecular complexes are essential to conserved biological processes, but their prevalence across animals is unclear. By combining extensive biochemical fractionation with quantitative mass spectrometry, here we directly examined the composition of soluble multiprotein complexes among diverse metazoan models. Using an integrative approach, we generated a draft conservation map consisting of more than one million putative high-confidence co-complex interactions for species ... [more]
Nature Sep. 17, 2015; 525(7569);339-44 [Pubmed: 26344197]
Quantitative Score
- 0.070968525 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- Fractionation was combined with mass spectrometry from five diverse animal species to predict co-complex protein interactions conserved across metazoa using an integrative computational scoring procedure along with an SVM approach. The significant data set of 16655 PPI, was derived from a set of more than 1M interactions by examining a ROC curve of predicted interactions against reference annotated complexes at a 67.5% cumulative precision.
Curated By
- BioGRID