COX4I1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NDUFS4
Gene Ontology Biological Process
- brain development [IMP]
- cAMP-mediated signaling [IMP]
- cellular metabolic process [TAS]
- cellular respiration [IMP]
- mitochondrial electron transport, NADH to ubiquinone [NAS]
- mitochondrial respiratory chain complex I assembly [IMP]
- positive regulation of fibroblast proliferation [IMP]
- reactive oxygen species metabolic process [IMP]
- regulation of protein phosphorylation [IMP]
- respiratory electron transport chain [TAS]
- response to cAMP [IMP]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Panorama of ancient metazoan macromolecular complexes
Macromolecular complexes are essential to conserved biological processes, but their prevalence across animals is unclear. By combining extensive biochemical fractionation with quantitative mass spectrometry, here we directly examined the composition of soluble multiprotein complexes among diverse metazoan models. Using an integrative approach, we generated a draft conservation map consisting of more than one million putative high-confidence co-complex interactions for species ... [more]
Quantitative Score
- 0.332357154 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- Fractionation was combined with mass spectrometry from five diverse animal species to predict co-complex protein interactions conserved across metazoa using an integrative computational scoring procedure along with an SVM approach. The significant data set of 16655 PPI, was derived from a set of more than 1M interactions by examining a ROC curve of predicted interactions against reference annotated complexes at a 67.5% cumulative precision.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
COX4I1 NDUFS4 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | 60 | BioGRID | 2984067 |
Curated By
- BioGRID