BAIT
NF1
NFNS, VRNF, WSS
neurofibromin 1
GO Process (49)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- MAPK cascade [ISS]
- Ras protein signal transduction [ISS]
- Schwann cell development [ISS]
- actin cytoskeleton organization [ISS]
- adrenal gland development [ISS]
- artery morphogenesis [ISS]
- brain development [ISS]
- camera-type eye morphogenesis [ISS]
- cell communication [ISS]
- cerebral cortex development [ISS]
- cognition [IMP]
- collagen fibril organization [ISS]
- extracellular matrix organization [ISS]
- forebrain astrocyte development [ISS]
- forebrain morphogenesis [ISS]
- heart development [ISS]
- liver development [ISS]
- metanephros development [ISS]
- myelination in peripheral nervous system [ISS]
- negative regulation of MAP kinase activity [ISS]
- negative regulation of MAPK cascade [IMP, ISS]
- negative regulation of Ras protein signal transduction [IBA]
- negative regulation of cell migration [IMP]
- negative regulation of endothelial cell proliferation [IMP]
- negative regulation of fibroblast proliferation [ISS]
- negative regulation of neuroblast proliferation [ISS]
- negative regulation of oligodendrocyte differentiation [ISS]
- negative regulation of protein kinase activity [ISS]
- negative regulation of transcription factor import into nucleus [ISS]
- osteoblast differentiation [ISS]
- peripheral nervous system development [ISS]
- phosphatidylinositol 3-kinase signaling [ISS]
- pigmentation [ISS]
- positive regulation of Ras GTPase activity [IDA, IMP, ISS]
- positive regulation of adenylate cyclase activity [ISS]
- positive regulation of apoptotic process [ISS]
- positive regulation of neuron apoptotic process [ISS]
- regulation of Ras GTPase activity [IMP]
- regulation of angiogenesis [IMP]
- regulation of blood vessel endothelial cell migration [IMP]
- regulation of bone resorption [ISS]
- regulation of cell-matrix adhesion [ISS]
- regulation of glial cell differentiation [ISS]
- response to hypoxia [ISS]
- smooth muscle tissue development [ISS]
- spinal cord development [ISS]
- sympathetic nervous system development [ISS]
- visual learning [ISS]
- wound healing [ISS]
Gene Ontology Molecular Function
Homo sapiens
PREY
NOSIP
CGI-25
nitric oxide synthase interacting protein
GO Process (5)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Panorama of ancient metazoan macromolecular complexes
Macromolecular complexes are essential to conserved biological processes, but their prevalence across animals is unclear. By combining extensive biochemical fractionation with quantitative mass spectrometry, here we directly examined the composition of soluble multiprotein complexes among diverse metazoan models. Using an integrative approach, we generated a draft conservation map consisting of more than one million putative high-confidence co-complex interactions for species ... [more]
Nature Sep. 17, 2015; 525(7569);339-44 [Pubmed: 26344197]
Quantitative Score
- 0.080059789 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- Fractionation was combined with mass spectrometry from five diverse animal species to predict co-complex protein interactions conserved across metazoa using an integrative computational scoring procedure along with an SVM approach. The significant data set of 16655 PPI, was derived from a set of more than 1M interactions by examining a ROC curve of predicted interactions against reference annotated complexes at a 67.5% cumulative precision.
Curated By
- BioGRID