BAIT
ATP6V1A
ATP6A1, ATP6V1A1, HO68, VA68, VPP2, Vma1
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
GO Process (7)
GO Function (0)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
PREY
PDCD10
CCM3, TFAR15
programmed cell death 10
GO Process (20)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- Golgi reassembly [IMP]
- establishment of Golgi localization [IMP]
- intrinsic apoptotic signaling pathway in response to hydrogen peroxide [IGI]
- negative regulation of apoptotic process [IDA]
- negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [IMP]
- negative regulation of cell migration involved in sprouting angiogenesis [IMP]
- negative regulation of gene expression [IMP]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of Notch signaling pathway [IMP]
- positive regulation of cell migration [IDA, IMP]
- positive regulation of cell proliferation [IDA]
- positive regulation of gene expression [IMP]
- positive regulation of peptidyl-serine phosphorylation [IMP]
- positive regulation of protein serine/threonine kinase activity [IMP]
- positive regulation of stress-activated MAPK cascade [IDA]
- protein stabilization [IMP]
- regulation of Rho protein signal transduction [IMP]
- response to hydrogen peroxide [IDA]
- stress fiber assembly [IMP]
- wound healing, spreading of cells [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Panorama of ancient metazoan macromolecular complexes
Macromolecular complexes are essential to conserved biological processes, but their prevalence across animals is unclear. By combining extensive biochemical fractionation with quantitative mass spectrometry, here we directly examined the composition of soluble multiprotein complexes among diverse metazoan models. Using an integrative approach, we generated a draft conservation map consisting of more than one million putative high-confidence co-complex interactions for species ... [more]
Nature Sep. 17, 2015; 525(7569);339-44 [Pubmed: 26344197]
Quantitative Score
- 0.159098937 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- Fractionation was combined with mass spectrometry from five diverse animal species to predict co-complex protein interactions conserved across metazoa using an integrative computational scoring procedure along with an SVM approach. The significant data set of 16655 PPI, was derived from a set of more than 1M interactions by examining a ROC curve of predicted interactions against reference annotated complexes at a 67.5% cumulative precision.
Curated By
- BioGRID