BAIT
TRIO
ARHGEF23, tgat
trio Rho guanine nucleotide exchange factor
GO Process (8)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- apoptotic signaling pathway [TAS]
- axon guidance [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of GTPase activity [TAS]
- positive regulation of apoptotic process [TAS]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
- transmembrane receptor protein tyrosine phosphatase signaling pathway [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
PPM1F
CAMKP, CaMKPase, FEM-2, POPX2, hFEM-2
protein phosphatase, Mg2+/Mn2+ dependent, 1F
GO Process (15)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- cellular response to drug [IDA]
- intrinsic apoptotic signaling pathway [IDA]
- negative regulation of peptidyl-serine phosphorylation [IDA]
- negative regulation of protein kinase activity [IDA]
- negative regulation of protein kinase activity by regulation of protein phosphorylation [IDA]
- negative regulation of transcription, DNA-templated [IMP]
- peptidyl-threonine dephosphorylation [IDA]
- positive regulation of cell-substrate adhesion [IMP]
- positive regulation of chemotaxis [IMP]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- positive regulation of epithelial cell migration [IMP]
- positive regulation of focal adhesion assembly [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of growth [IMP]
- positive regulation of stress fiber assembly [IDA, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Panorama of ancient metazoan macromolecular complexes
Macromolecular complexes are essential to conserved biological processes, but their prevalence across animals is unclear. By combining extensive biochemical fractionation with quantitative mass spectrometry, here we directly examined the composition of soluble multiprotein complexes among diverse metazoan models. Using an integrative approach, we generated a draft conservation map consisting of more than one million putative high-confidence co-complex interactions for species ... [more]
Nature Sep. 17, 2015; 525(7569);339-44 [Pubmed: 26344197]
Quantitative Score
- 0.30454515 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- Fractionation was combined with mass spectrometry from five diverse animal species to predict co-complex protein interactions conserved across metazoa using an integrative computational scoring procedure along with an SVM approach. The significant data set of 16655 PPI, was derived from a set of more than 1M interactions by examining a ROC curve of predicted interactions against reference annotated complexes at a 67.5% cumulative precision.
Curated By
- BioGRID