PABPC4
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PPT1
Gene Ontology Biological Process
- brain development [IMP]
- cofactor metabolic process [IMP]
- cofactor transport [IMP]
- lipid catabolic process [IDA]
- lysosomal lumen acidification [IMP]
- membrane raft organization [IMP]
- negative regulation of apoptotic process [IDA]
- negative regulation of cell growth [IMP]
- negative regulation of neuron apoptotic process [IMP]
- nervous system development [IMP]
- neuron development [TAS]
- pinocytosis [IMP]
- positive regulation of pinocytosis [IMP]
- positive regulation of receptor-mediated endocytosis [IMP]
- protein catabolic process [NAS]
- protein depalmitoylation [IDA, ISS]
- protein transport [IMP]
- receptor-mediated endocytosis [IMP]
- regulation of synapse structure or activity [NAS]
- sphingolipid catabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Panorama of ancient metazoan macromolecular complexes
Macromolecular complexes are essential to conserved biological processes, but their prevalence across animals is unclear. By combining extensive biochemical fractionation with quantitative mass spectrometry, here we directly examined the composition of soluble multiprotein complexes among diverse metazoan models. Using an integrative approach, we generated a draft conservation map consisting of more than one million putative high-confidence co-complex interactions for species ... [more]
Quantitative Score
- 0.071463489 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- Fractionation was combined with mass spectrometry from five diverse animal species to predict co-complex protein interactions conserved across metazoa using an integrative computational scoring procedure along with an SVM approach. The significant data set of 16655 PPI, was derived from a set of more than 1M interactions by examining a ROC curve of predicted interactions against reference annotated complexes at a 67.5% cumulative precision.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PPT1 PABPC4 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID